Mechanisms of Exacerbation of Asthma (MECA)
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ClinicalTrials.gov Identifier: NCT00594750 |
Recruitment Status :
Active, not recruiting
First Posted : January 16, 2008
Last Update Posted : February 1, 2022
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Condition or disease |
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Asthma |
Study Type : | Observational |
Estimated Enrollment : | 115 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | Mechanisms of Exacerbation of Asthma |
Study Start Date : | May 2006 |
Estimated Primary Completion Date : | September 2022 |
Estimated Study Completion Date : | December 2022 |
Group/Cohort |
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Asthma
People who have been diagnosed with Asthma
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- rheological measurements (viscosity and elasticity) in sputum from patients with acute severe asthma [ Time Frame: 1-2 years ]
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Male and female subjects with a history of asthma between the ages of 18 to 75 years.
- Physician diagnosis of asthma.
- Currently experiencing an acute exacerbation of asthma. This exacerbation may be severe necessitating treatment in the emergency room, ICU, or hospital ward.
- Ability to provide informed consent.
Exclusion Criteria:
- Lung disease other than asthma.
- Females who are lactating or who are pregnant.
- Use of recreational drugs in the 1 month preceding the study.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00594750
United States, California | |
UCSF Airway Clinical Research Center | |
San Francisco, California, United States, 94143 |
Principal Investigator: | John V Fahy, M.D., M.Sc. | University of California, San Francisco |
Responsible Party: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00594750 |
Other Study ID Numbers: |
10-01329 5R01HL080414-08 ( U.S. NIH Grant/Contract ) |
First Posted: | January 16, 2008 Key Record Dates |
Last Update Posted: | February 1, 2022 |
Last Verified: | January 2022 |
Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases |