Mechanisms of Exacerbation of Asthma (MECA)
This study is currently recruiting participants.
(see Contacts and Locations)
Verified June 2016 by University of California, San Francisco
Sponsor:
University of California, San Francisco
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT00594750
First received: January 2, 2008
Last updated: June 1, 2016
Last verified: June 2016
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Purpose
The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma.
| Condition |
|---|
|
Asthma |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
| Official Title: | Mechanisms of Exacerbation of Asthma |
Further study details as provided by University of California, San Francisco:
Primary Outcome Measures:
- rheological measurements (viscosity and elasticity) in sputum from patients with acute severe asthma [ Time Frame: 1-2 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Sputum, whole blood
| Estimated Enrollment: | 115 |
| Study Start Date: | May 2006 |
| Estimated Study Completion Date: | December 2017 |
| Estimated Primary Completion Date: | June 2017 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Asthma
People who have been diagnosed with Asthma
|
Detailed Description:
In this study, we will explore mechanisms of exacerbation in asthma by careful characterization studies in asthmatics presenting in acute severe exacerbation. Specifically, we will determine the frequency of secretor status in these subjects by blood and saliva testing, and we will also perform a detailed cellular and biochemical analysis of their airway secretions. We will collect airway secretions using two methods. One method will be to have subjects cough sputum into a clean plastic container. The other method only applies to asthmatics with near-fatal asthma requiring intubation and mechanical ventilation. In these asthmatics, we will collect airway secretions by tracheal aspirate using methods normally applied in their clinical care.
Eligibility| Ages Eligible for Study: | 18 Years to 75 Years (Adult, Senior) |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
emergency deparment, admitted patients in the ICU and inpatient wards
Criteria
Inclusion Criteria:
- Male and female subjects with a history of asthma between the ages of 18 to 75 years.
- Physician diagnosis of asthma.
- Currently experiencing an acute exacerbation of asthma. This exacerbation may be severe necessitating treatment in the emergency room, ICU, or hospital ward.
- Ability to provide informed consent.
Exclusion Criteria:
- Lung disease other than asthma.
- Females who are lactating or who are pregnant.
- Use of recreational drugs in the 1 month preceding the study.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00594750
Please refer to this study by its ClinicalTrials.gov identifier: NCT00594750
Contacts
| Contact: Ariana Baum | 415-514-1539 | ariana.baum@ucsf.edu |
Locations
| United States, California | |
| UCSF Airway Clinical Research Center | Recruiting |
| San Francisco, California, United States, 94143 | |
| Contact: Ariana Baum 415-514-1539 ariana.baum@ucsf.edu | |
Sponsors and Collaborators
University of California, San Francisco
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
| Principal Investigator: | John V Fahy, M.D., M.Sc. | University of California, San Francisco |
More Information
Additional Information:
| Responsible Party: | University of California, San Francisco |
| ClinicalTrials.gov Identifier: | NCT00594750 History of Changes |
| Other Study ID Numbers: | 10-01329 5R01HL080414-08 |
| Study First Received: | January 2, 2008 |
| Last Updated: | June 1, 2016 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Asthma Bronchial Diseases Respiratory Tract Diseases Lung Diseases, Obstructive Lung Diseases |
Respiratory Hypersensitivity Hypersensitivity, Immediate Hypersensitivity Immune System Diseases |
ClinicalTrials.gov processed this record on September 30, 2016