This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy

This study has been completed.
University of Eastern Finland
Information provided by (Responsible Party):
Taru Grohn, Kuopio University Hospital Identifier:
First received: January 7, 2008
Last updated: October 28, 2011
Last verified: October 2011

Outcome of psychodynamic psychotherapy measured by [123I] nor-B-CIT SPET imaging

Background Psychodynamic psychotherapy is a widely practised form of psychotherapy in the treatment of depression. There is evidence that serotonin transporter (SERT) densities are altered in depression. Preliminary observations have suggested that SERT function may recover in connection with dynamic psychotherapy.

The objective was to determine whether SERT densities change in relation to clinical recovery during psychodynamic psychotherapy.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by Taru Grohn, Kuopio University Hospital:

Biospecimen Retention:   Samples With DNA
DNA, creatine, B-vitamin,BP from blood samples.

Enrollment: 26
Study Start Date: January 2000
Study Completion Date: December 2008

Detailed Description:


Method Twenty six drug-naïve currently depressed (moderate/severe) patients with no previous treatment were recruited for the study. The baseline study included a group of 18 healthy controls. The patients were randomised into psychotherapy and waiting-list control groups. For controls, psychotherapy was started after a 6-month waiting period. [123I] nor-B-CIT SPET imaging was performed at baseline and after 12 months of psychotherapy. For the controls, additional imaging was performed after the 6-month waiting period.


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patiens of clinic

Inclusion Criteria:

  • depression

Exclusion Criteria:

  • antidepressive medication
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00594711

Sponsors and Collaborators
Kuopio University Hospital
University of Eastern Finland
Principal Investigator: Pirjo Saarinen, Ph.D. Kuopio University Hospital
Study Director: Johannes Lehtonen, Ph.D Kuopio University Hospital
Study Chair: Lehto Soili, MD Kuopio University Hospital
Study Chair: Minna Valkonen-Korhonen, Ph.D Kuopio University
Study Chair: Pasi Ahola, MD Kuopio University
Study Chair: Mikko Joensuu, MD Kuopio University Hospital
Study Chair: Tommi Tolmunen, Ph.D. Kuopio University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Taru Grohn, Pirjo Saarinen, Kuopio University Hospital Identifier: NCT00594711     History of Changes
Other Study ID Numbers: KUH5703410
Study First Received: January 7, 2008
Last Updated: October 28, 2011

Keywords provided by Taru Grohn, Kuopio University Hospital:

Additional relevant MeSH terms:
Behavioral Symptoms processed this record on August 18, 2017