Development and Efficacy Test of Computerized Treatment for Marijuana Dependence
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|ClinicalTrials.gov Identifier: NCT00594659|
Recruitment Status : Completed
First Posted : January 16, 2008
Results First Posted : December 4, 2013
Last Update Posted : December 4, 2013
More US residents are dependent on marijuana than on any other illicit drug, and the number enrolled in treatment for marijuana continues to increase such that it is now comparable to that for cocaine and heroin. This application seeks to advance the overarching goal to develop and disseminate cost-effective treatments for marijuana dependence that can address this growing problem.
The researchers' previous research suggests that an intervention comprising motivational enhancement, cognitive-behavioral, and contingency-management components (MET/CBT/CM) produces greater rates of successful and durable outcomes than has been demonstrated previously. However, three issues relevant to its efficacy and eventual dissemination must be confronted. First, the outcomes achieved can only be characterized as modest; many individuals do not respond to the treatment and relapse rates remain problematic. Second, access is limited by the availability of trained providers. Third, the cost of delivering the treatment is higher than more traditional outpatient interventions.
To address these issues, Specific Aim 1 is to develop and test a computer-assisted version of MET/CBT/CM. Computerized treatments have the potential to increase overall effectiveness of treatment services by increasing availability of and access to potent treatments, and by applying innovative technology to enhance outcomes. During Year 1, the intervention will be developed and pilot tested. An interactive program that showed promise in a previous trial for opioid dependence will be modified and enhanced to deliver individualized MET/CBT/CM using effective computer learning technologies. These technologies and access to the MET/CBT/CM program made available via the Internet between treatment sessions and after treatment ends have the potential to promote better learning and more use of coping skills, which in turn can improve outcomes. During Years 2-4 a randomized trial will provide an initial efficacy test of cMET/CBT/CM by comparing it with a brief treatment (MET) and with therapist-delivered MET/CBT/CM. Specific Aim 2 is to learn more about how behavioral treatments like MET/CBT/CM work by focusing on two putative mechanisms of action examined in prior trials: self-efficacy/coping skills and impulsivity/delay discounting. The experimental design will provide a unique opportunity to explore such mechanisms in a novel context- where the therapist is vs. is not a prominent part of the treatment.
The proposed project will address the objectives of NIDA's Behavioral and Integrative Treatment Development Program by providing research on technology-assisted treatment that attempts to make treatment delivery less complex, easier to access, and less costly - while retaining or improving its effectiveness. Findings will inform future studies designed to refine the technology and how it is applied; conduct more definitive effectiveness testing; test generality to other populations including adolescents; and to further advance translation to community settings.
|Condition or disease||Intervention/treatment||Phase|
|Marijuana Abuse and Dependence||Behavioral: Psychotherapy Behavioral: Computerized Psychotherapy Behavioral: Motivational enhancement therapy||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||75 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Development and Efficacy Test of Computerized Treatment for Marijuana Dependence|
|Study Start Date :||November 2008|
|Actual Primary Completion Date :||July 2012|
|Actual Study Completion Date :||July 2012|
Active Comparator: 1
Therapist delivered cognitive behavioral treatment
Nine session treatment
Computerized Cognitive Behavioral treatment
Behavioral: Computerized Psychotherapy
Nine session computer delivered treatment
Active Comparator: 3
Motivational enhancement therapy
Behavioral: Motivational enhancement therapy
Two session treatment
- Consecutive Weeks of Marijuana Abstinence [ Time Frame: From the start of treatment through the end of the active treatment period, i.e., 12 weeks. ]Longest period of marijuana abstinence achieved during the 12-week treatment period documented by urine testing and self-report.
- Point Prevalence Abstinence Post Treatment [ Time Frame: 9 months (from the end of treatment to 9 months post-treatment). ]Percent of participants that were marijuana abstinent based on urine toxicology testing at each follow up assessment across 9 month follow up period ( at the end of treatment, at 3-months, 6-months, and 9 months post the end of treatment).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00594659
|United States, New Hampshire|
|Geisel School of Medicine at Dartmouth|
|Lebanon, New Hampshire, United States, 03756|
|Principal Investigator:||Alan J Budney, Ph.D.||Dartmouth College|