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Effects of Medical and Surgical Weight Loss on Metabolism (BOS)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Professor Katherine Samaras, Garvan Institute of Medical Research
ClinicalTrials.gov Identifier:
NCT00592735
First received: January 1, 2008
Last updated: June 5, 2016
Last verified: June 2016
  Purpose
This study will follow ,morbidly obese subjects as they undertake weight loss before and after laparoscopic gastric banding, examining markers of glucose and lipid metabolism, adipokines and measures of body fat.

Condition Intervention
Type 2 Diabetes
Obesity
Procedure: laparoscopic gastric banding

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Role of Adipocyte-derived Inflammatory Cytokines in the Pathogenesis of Diabetes, Dyslipidaemia, Atherosclerosis and Gastro-oesophageal Reflux Disease: the Effects of Medical and Surgical Weight Loss

Resource links provided by NLM:


Further study details as provided by Garvan Institute of Medical Research:

Primary Outcome Measures:
  • weight loss [ Time Frame: 6 months ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
serum, tissue

Enrollment: 20
Study Start Date: May 2007
Study Completion Date: May 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1 Procedure: laparoscopic gastric banding
standard surgical procedure

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
morbidly obese subjects with type 2 diabetes or metabolic syndrome
Criteria

Inclusion Criteria:

  • morbidly obese subjects with type 2 diabetes or metabolic syndrome
  • age <70

Exclusion Criteria:

  • contra-indications to bariatric surgery
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00592735

Locations
Australia, New South Wales
St Vincent's Hospital
Sydney, New South Wales, Australia, 2010
Sponsors and Collaborators
Garvan Institute of Medical Research
  More Information

Responsible Party: Professor Katherine Samaras, Garvan Institute of Medical Research
ClinicalTrials.gov Identifier: NCT00592735     History of Changes
Other Study ID Numbers: SVH H06/151 
Study First Received: January 1, 2008
Last Updated: June 5, 2016
Health Authority: Australia: Human Research Ethics Committee

Additional relevant MeSH terms:
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on September 29, 2016