Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry
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ClinicalTrials.gov Identifier: NCT00592709 |
Recruitment Status
:
Completed
First Posted
: January 14, 2008
Last Update Posted
: April 4, 2017
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Condition or disease |
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Brain Diseases |
We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery for other non-cancerous types of brain tissus. These specimens will then be studied using a novel microscopic laser-directed protein mass spectrometric analysis. Data from different brain tissues including tumors of different histological sub-types will be analyzed for unique protein signatures. These protein signatures will then be statistically correlated with clinical data including time to tumor progression and response to therapy.
The goal of this study is to determine molecular patterns that will be more predictive of tumor behavior, thus leading to an improved understanding of the basic biology of these poorly understood cancers. This in turn, may lead to more refined therapies and improved outcomes.
Study Type : | Observational |
Actual Enrollment : | 84 participants |
Observational Model: | Other |
Time Perspective: | Retrospective |
Official Title: | Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry |
Study Start Date : | May 2003 |
Actual Primary Completion Date : | December 2010 |
Actual Study Completion Date : | December 2012 |
- measurement of proteomic signatures in brain tumor samples [ Time Frame: immediately upon analysis of the sample ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 2 Years to 85 Years (Child, Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- A diagnosis of brain tumor or other non-cancerous tissue and are considered candidates fro a surgical procedure to biopsy or remove the brain tumor or other tissue type at Vanderbilt University Medical Center.
- Age 2 to 85
Exclusion Criteria:
- Patient or guardian that is unable to understand the informed consent process.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00592709
United States, Tennessee | |
Vanderbilt University Medical Center, Department of Neurological Surgery | |
Nashville, Tennessee, United States, 37232 |
Principal Investigator: | Reid C. Thompson, MD | Vanderbilt University Medical Center, Department of Neurological Surgery |
Responsible Party: | Reid Thompson, Professor of Neurological Surgery, Vanderbilt University Medical Center |
ClinicalTrials.gov Identifier: | NCT00592709 History of Changes |
Other Study ID Numbers: |
030258 |
First Posted: | January 14, 2008 Key Record Dates |
Last Update Posted: | April 4, 2017 |
Last Verified: | March 2017 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Additional relevant MeSH terms:
Brain Neoplasms Brain Diseases Central Nervous System Neoplasms Nervous System Neoplasms |
Neoplasms by Site Neoplasms Central Nervous System Diseases Nervous System Diseases |