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Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Reid Thompson, Vanderbilt University Medical Center
ClinicalTrials.gov Identifier:
NCT00592709
First received: January 2, 2008
Last updated: March 30, 2017
Last verified: March 2017
History of Changes
  Purpose
We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery for other non-cancerous types of brain tissus. These specimens will then be studied using a novel microscopic laser-directed protein mass spectrometric analysis, looking for unique protein signatures.

Condition
Brain Diseases

Study Type: Observational
Study Design: Observational Model: Other
Time Perspective: Retrospective
Official Title: Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Reid Thompson, Vanderbilt University Medical Center:

Primary Outcome Measures:
  • measurement of proteomic signatures in brain tumor samples [ Time Frame: immediately upon analysis of the sample ]

Biospecimen Retention:   Samples With DNA
Brain Tissue

Enrollment: 84
Study Start Date: May 2003
Study Completion Date: December 2012
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Detailed Description:

We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery for other non-cancerous types of brain tissus. These specimens will then be studied using a novel microscopic laser-directed protein mass spectrometric analysis. Data from different brain tissues including tumors of different histological sub-types will be analyzed for unique protein signatures. These protein signatures will then be statistically correlated with clinical data including time to tumor progression and response to therapy.

The goal of this study is to determine molecular patterns that will be more predictive of tumor behavior, thus leading to an improved understanding of the basic biology of these poorly understood cancers. This in turn, may lead to more refined therapies and improved outcomes.

  Eligibility
Ages Eligible for Study:   2 Years to 85 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Age 2 years through Age 85 years old
Criteria

Inclusion Criteria:

  • A diagnosis of brain tumor or other non-cancerous tissue and are considered candidates fro a surgical procedure to biopsy or remove the brain tumor or other tissue type at Vanderbilt University Medical Center.
  • Age 2 to 85

Exclusion Criteria:

  • Patient or guardian that is unable to understand the informed consent process.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00592709

Locations
United States, Tennessee
Vanderbilt University Medical Center, Department of Neurological Surgery
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Vanderbilt University
Investigators
Principal Investigator: Reid C. Thompson, MD Vanderbilt University Medical Center, Department of Neurological Surgery
  More Information

Responsible Party: Reid Thompson, Professor of Neurological Surgery, Vanderbilt University Medical Center
ClinicalTrials.gov Identifier: NCT00592709     History of Changes
Other Study ID Numbers: 030258
Study First Received: January 2, 2008
Last Updated: March 30, 2017
Individual Participant Data  
Plan to Share IPD: No

Additional relevant MeSH terms:
Brain Neoplasms
Brain Diseases
Central Nervous System Neoplasms
Nervous System Neoplasms
 Neoplasms by Site
Neoplasms
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on June 23, 2017