Effect of NAC on Sleep Apnea

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00592618
Recruitment Status : Unknown
Verified May 2007 by Assaf-Harofeh Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : January 14, 2008
Last Update Posted : January 14, 2008
Information provided by:
Assaf-Harofeh Medical Center

Brief Summary:
Sleep studies in ESRD patients have identified increased prevalence of Sleep Apnea. Based on current knowledge, treatment aimed at reducing oxidative stress might improve Sleep Apnea in HD patients. The aim of our study is to investigate the effect of N-acetylsysteine on Sleep Apnea in HD patients.

Condition or disease Intervention/treatment Phase
ESRD Sleep Apnea Drug: Oral N-Acetylcysteine 1200 mg x 2/day for 4 weeks Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sleep Apnea
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • The study will include 20 patients with ESRD, treated with chronic hemodialysis in Assaf Harofeh Medical Center and suffering from sleep disturbances, such as frequent arousals, snoring, daytime sleepiness.

Exclusion Criteria:

Patients will be excluded from the study if they are:

  • Recently started treated with chronic dialysis: less than 3 months.
  • Survived recent major illness, requiring hospitalisation in the last 3 months.
  • Patients with acute renal failure
  • Currently treated with antioxidants ( NAC, vitamin E ets.)
  • Current use of sleep pills

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00592618

Contact: Leonid S Feldman, MD +972-8-9779383

Nephrology Division, Assaf Harofeh Medical Center Not yet recruiting
Zerifin, Israel, 70300
Contact: Leonid S Feldman    +972-8-9779383   
Sponsors and Collaborators
Assaf-Harofeh Medical Center
Principal Investigator: Leonid S Feldman, MD Assaf Harofeh MC Identifier: NCT00592618     History of Changes
Other Study ID Numbers: 346147SLEEP
First Posted: January 14, 2008    Key Record Dates
Last Update Posted: January 14, 2008
Last Verified: May 2007

Keywords provided by Assaf-Harofeh Medical Center:
Sleep Apnea

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases
Antiviral Agents
Anti-Infective Agents
Respiratory System Agents
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs