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Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities

This study has been terminated.
Information provided by (Responsible Party):
Yale University Identifier:
First received: January 2, 2008
Last updated: July 1, 2014
Last verified: July 2014
The purpose of this study is to determine whether dynamic contrast enhanced MRI (DCE MRI) and high diffusion weighting MRI may be used to distinguish between favorable and unfavorable responses to therapy of glioblastoma multiforme. Imaging data will be correlated with histopathologic findings and clinical responses to radiation therapy with or without chemotherapy.

Condition Intervention
Glioblastoma Multiforme
Other: dynamic contrast enhanced magnetic resonance imaging

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities

Resource links provided by NLM:

Further study details as provided by Yale University:

Primary Outcome Measures:
  • To detect the early "local" treatment responses from the physician recognized GBM "gross tumor volume" (GTV) [ Time Frame: Upon completion of study ]

Estimated Enrollment: 5
Study Start Date: November 2006
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1 Other: dynamic contrast enhanced magnetic resonance imaging
dynamic contrast enhanced MRI using contrast agent gadodiamide
Other Name: Omniscan


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients referred to the Yale Brain Tumor Center for management of glioblastome multiforme

Inclusion Criteria:

  • The presence of a primary brain tumor that cannot be completely resected that requires radiation therapy with or without chemotherapy.

Exclusion Criteria:

  • Patients who do not have a primary brain tumor or who are unable to tolerate the environment of the MRI scanner
  Contacts and Locations
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Please refer to this study by its identifier: NCT00589095

United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06520
Sponsors and Collaborators
Yale University
Principal Investigator: Jonathan Knisely, M.D. Yale University
  More Information

Responsible Party: Yale University Identifier: NCT00589095     History of Changes
Other Study ID Numbers: 0606001531
Study First Received: January 2, 2008
Last Updated: July 1, 2014

Additional relevant MeSH terms:
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue processed this record on May 25, 2017