Study of Fibrinogen Metabolism During Severe Trauma and Burns
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries|
- During the flow phase following burn or trauma injury, fibrinogen degradation is accelerated [ Time Frame: 7 ] [ Designated as safety issue: No ]
- Fibrinogen degradation stimulates fibrinogen synthesis at the expense of whole body protein catabolism [ Time Frame: 7 days ] [ Designated as safety issue: No ]
|Study Start Date:||February 2005|
|Study Completion Date:||January 2014|
|Primary Completion Date:||January 2014 (Final data collection date for primary outcome measure)|
Patients who have sustained burn injury greater than or equal to 20% of total body surface area
Patients who have undergone trauma
In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00588796
|Principal Investigator:||Wenjun Z Martini, PhD||United States Army Institute of Surgical Research|