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Endoscopic Mucosal Resection (EMR) in Barrett's Esophagus

This study is enrolling participants by invitation only.
Information provided by (Responsible Party):
Kenneth K. Wang, Mayo Clinic Identifier:
First received: December 21, 2007
Last updated: January 24, 2017
Last verified: January 2017
Existing records will be reviewed to evaluate the predictors of complications including stricture formation, bleeding or perforation associated with endoscopic mucosal resection

Barrett's Esophagus Early Esophageal Adenocarcinoma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Endoscopic Mucosal Resection in Barrett's Esophagus

Resource links provided by NLM:

Further study details as provided by Kenneth K. Wang, Mayo Clinic:

Primary Outcome Measures:
  • Number and types of adverse events in participants who have undergone endoscopic mucosal resection with documented adverse events will be evaluated for predictors of complications [ Time Frame: 3 months after EMR procedure ]

Estimated Enrollment: 1800
Study Start Date: October 2007
Estimated Study Completion Date: October 2017
Estimated Primary Completion Date: October 2017 (Final data collection date for primary outcome measure)
patients with barretts esophagus and/or early esophageal adenocarcinoma who have undergone endoscopic mucosal resection

Detailed Description:
Barrett's esophagus (BE) is a complication of gastroesophageal reflux disease in which the normal squamous lining of the esophagus is replaced by specialized columnar epithelium.1 Approximately 5%-10% of patients diagnosed with BE are thought to be at risk of developing esophageal adenocarcinoma.2 Patients with high-grade dysplasia (HGD) on biopsy are at the greatest cancer risk³. EMR is being performed clinically in our Barrett's Esophagus Unit on a regular basis during endoscopy for patients with Barrett's Esophagus and/or early esophageal adenocarcinoma. There are two predominant endoscopic mucosal resection (EMR) techniques exist using FDA approved devices - the EMR cap method using a transparent cap/snare combination and the endoscopic variceal ligation method using a band ligator/snare combination to resect tissue.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients who have had endoscopic mucosal resection

Inclusion Criteria:

  • Barrett's Esophagus Early Esophageal Adenocarcinoma History of Endoscopic Mucosal Resection

Exclusion Criteria:

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00586872

United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Principal Investigator: Kenneth K Wang, MD Mayo Clinic
  More Information

Additional Information:
Responsible Party: Kenneth K. Wang, MD, Mayo Clinic Identifier: NCT00586872     History of Changes
Other Study ID Numbers: 07-007063
07-007063 ( Other Identifier: Mayo Clinic IRB )
Study First Received: December 21, 2007
Last Updated: January 24, 2017

Keywords provided by Kenneth K. Wang, Mayo Clinic:
Barrett's Esophagus
Early Esophageal Adenocarcinoma
Endoscopic Mucosal Resection

Additional relevant MeSH terms:
Barrett Esophagus
Esophageal Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Digestive System Abnormalities
Digestive System Diseases
Esophageal Diseases
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Head and Neck Neoplasms processed this record on September 19, 2017