Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00584259
Recruitment Status : Completed
First Posted : January 2, 2008
Last Update Posted : July 13, 2010
Information provided by:
University of California, Davis

Brief Summary:
Investigation evaluating the effect of coffee on gastro-esophageal reflux disease.

Condition or disease Intervention/treatment Phase
GERD Other: Coffee Not Applicable

Detailed Description:
Many patients with gastro-esophageal reflux disease (GERD) report that drinking coffee causes heartburn. The purpose of this study is to investigate the effects of coffee on gastro-esophageal acid reflux, and its relation to esophageal motility parameters in patients who are already scheduled to undergo 48 hour wireless pH testing as a result of having symptoms suggestive of GERD. The specific aims are to evaluate the effects of coffee on GERD during daily life and to elucidate the underlying pathogenic mechanism by which coffee induces reflux.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 7 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Official Title: Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux
Study Start Date : May 2006
Actual Primary Completion Date : January 2010
Actual Study Completion Date : January 2010

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Intervention Details:
    Other: Coffee
    3 cups of coffee over a 24 hour period

Primary Outcome Measures :
  1. coffee leads to reflux events [ Time Frame: 48 hours ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • persons undergoing wireless pH testing for diagnosis and treatment of GERD

Exclusion Criteria:

  • those under the age of 18
  • pregnant and lactating women
  • those who do not meet the inclusion criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00584259

United States, California
University of California Davis Medical Center
Sacramento, California, United States, 95817
Sponsors and Collaborators
University of California, Davis
Principal Investigator: Peter Belafsky, MD, PhD University of California, Davis

Responsible Party: Peter Belafsky, MD, Ph.D., University of California Davis Identifier: NCT00584259     History of Changes
Other Study ID Numbers: 200614348-2
First Posted: January 2, 2008    Key Record Dates
Last Update Posted: July 13, 2010
Last Verified: July 2010

Keywords provided by University of California, Davis:
Gastro-Esophageal Disease

Additional relevant MeSH terms:
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases