This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Improving Walking in Older Adults With Knee Osteoarthritis

This study has been completed.
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Neil A Segal, University of Iowa Identifier:
First received: December 20, 2007
Last updated: March 7, 2017
Last verified: March 2017
Knee osteoarthritis (OA) accounts for a significant proportion of mobility limitations and is one of the most disabling problems facing the growing population of older adults. The long-term objective of this research is to reduce disablement of older adults with symptomatic knee OA. The principle of specificity of training indicates that exercises that closely approximate the goal functional activity are most effective in improving physical performance during that activity. Based on this principle, the specific aim of this pilot study is to design a patient-specific gait training intervention using analysis of compensatory joint moments and energy expenditure. Successful completion will inform rehabilitation for maintaining or improving mobility as well as explore the mechanism of effect.

Condition Intervention
Knee Osteoarthritis Other: Gait Training

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: No masking
Primary Purpose: Treatment
Official Title: Optimizing Mobility in Older Adults With Knee Osteoarthritis

Resource links provided by NLM:

Further study details as provided by Neil A Segal, University of Iowa:

Primary Outcome Measures:
  • Changes in functional limitation assessed by the A) Summary Performance Score which includes balance tests, timed 4-meter walk, and timed chair stand test B) Timed stair climb C) Late Life Function and Disability Instrument (LLFDI) Questionnaire [ Time Frame: 12 weeks ]
  • Changes in the disability measure, a timed 400 meter walk [ Time Frame: 12 Weeks ]
  • Changes in impairments assessed using the Knee and Osteoarthritis Outcome Score (KOOS) questionnaire [ Time Frame: 12 Weeks ]

Enrollment: 27
Study Start Date: December 2007
Study Completion Date: December 2009
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Gait training
Other: Gait Training
Gait training with physical therapist 2/week for 3 months


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Symptomatic knee osteoarthritis (knee osteoarthritis diagnosed by x-ray and frequent knee symptoms)
  • Age 60 or older

Exclusion Criteria:

  • acute or terminal illness
  • unstable cardiovascular condition or other medical conditions that may impair ability to participate such as pulmonary disease requiring the use of supplemental oxygen, neurological disease that affects gait, or lower limb musculoskeletal surgery in the past 6 months.
  • Bilateral knee replacement
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00583245

United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
Sponsors and Collaborators
University of Iowa
National Institute on Aging (NIA)
Principal Investigator: Neil Segal, MD University of Iowa
  More Information

Responsible Party: Neil A Segal, Professor, University of Iowa Identifier: NCT00583245     History of Changes
Other Study ID Numbers: 200704794
1K23AG030945-01 ( US NIH Grant/Contract Award Number )
Study First Received: December 20, 2007
Last Updated: March 7, 2017

Keywords provided by Neil A Segal, University of Iowa:
Gait training
Knee pain
Physical Therapy

Additional relevant MeSH terms:
Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on June 23, 2017