Development of an Algorithm for Prediction of Onset of Hemodynamic Instability in Humans
The purpose for this study is to measure the physiology of human undergoing a Lower Body Negative Pressure usea non-invasive low-power optical technique, near-infrared diffuse optical spectroscopy measurement and compare these measurement to standard monitoring procedures delineated in the Brooke Army Medical Center.
The Brooke Army Medical Center can use near-infrared diffuse optical spectroscopy to provide functional physiologic tissue and organ information without ionizing radiation and without withdrawing any blood, in a cost-effective and rapid manner. Monitoring for the onset of circulatory shock in a wounded soldier on the battlefield is typically performed by measurement of arterial blood pressure, arterial oxygen saturation, or simple auscultation of the pulse. Shock is typically recognized by non-specific signs and subjective symptoms such as cold clammy skin, pallor, weak thready pulse, unstable vital signs, and diminished mentation.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Development of an Algorithm for Prediction of Onset of Hemodynamic Instability in Humans|
- Early predictor of shock [ Time Frame: 5 to 60 seconds. ] [ Designated as safety issue: No ]The near-infrared diffuse optical spectroscopy measure tissues properties
|Study Start Date:||December 2011|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
Near-Infrared Diffuse Optical Spectroscopy Imaging
Device: Near-Infrared Diffuse Optical Spectroscopy
Early predictor of hemorrhagic shock
Other Name: Near-Infrared Diffuse Optical Spectroscopy Imaging
The near-infrared diffuse optical spectroscopy can measure tissue regions deeper below the skin surface and reports on larger tissue volumes in muscle and brain. The near-infrared diffuse optical spectroscopy instrument generate harmless amounts of low-level non-ionizing near-infrared ligh can measure the tissue absorption and scattering properties at depths of 1 cm or more below the skin surface include larger tissue volumes in muscle and brain. The absorption properties of tissue provide and can determine absolute concentrations of deoxygenated hemoglobin, oxygenated hemoglobin, and water, as well as the total hemoglobin saturation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00581204
|United States, California|
|Beckman Laser Institute,University of California, Irvine|
|Irvine, California, United States, 92612|
|Principal Investigator:||Matthew Brenner, M.D||Beckman Laser Institute University of California Irvine|