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Objective Sleep Disturbances in Orthostatic Intolerance

This study is ongoing, but not recruiting participants.
National Center for Research Resources (NCRR)
Information provided by (Responsible Party):
Satish R. Raj, Vanderbilt University Identifier:
First received: December 22, 2007
Last updated: August 15, 2016
Last verified: August 2016
We wish to study sleep architecture in patients with chronic orthostatic intolerance. We will test the null hypothesis that there is no difference in time during the various phases of sleep between patients and healthy control subjects.

Condition Intervention
Postural Tachycardia Syndrome
Chronic Orthostatic Intolerance
Procedure: Polysomnography

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessment of Objective Sleep Disturbances in Orthostatic Intolerance

Resource links provided by NLM:

Further study details as provided by Vanderbilt University:

Primary Outcome Measures:
  • Duration of sleep [ Time Frame: 1 night ]

Secondary Outcome Measures:
  • Time in individual phases of sleep [ Time Frame: 1 night ]
  • sleep latency [ Time Frame: 1 might ]

Estimated Enrollment: 100
Study Start Date: November 2006
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients with Chronic Orthostatic Intolerance
Procedure: Polysomnography
Overnight Sleep Study
Other Name: Sleep Study


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients diagnosed with chronic orthostatic intolerance by the Vanderbilt Autonomic Dysfunction Center

Inclusion Criteria:

  • diagnosed with chronic orthostatic intolerance (or healthy subject)

Exclusion Criteria:

  • overt cause or acute orthostatic intolerance
  • pregnancy or lactation
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Please refer to this study by its identifier: NCT00581022

United States, Tennessee
Vanderbilt Unviersity
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Satish R. Raj
National Center for Research Resources (NCRR)
Principal Investigator: Satish R Raj, MD MSCI Vanderbilt University
  More Information

Additional Information:
Responsible Party: Satish R. Raj, Assistant Professor of Medicine & Pharmacology, Vanderbilt University Identifier: NCT00581022     History of Changes
Other Study ID Numbers: 051131
UL1RR024975 ( US NIH Grant/Contract Award Number )
Study First Received: December 22, 2007
Last Updated: August 15, 2016

Keywords provided by Vanderbilt University:
postural tachycardia syndrome

Additional relevant MeSH terms:
Sleep Wake Disorders
Orthostatic Intolerance
Postural Orthostatic Tachycardia Syndrome
Nervous System Diseases
Mental Disorders
Neurologic Manifestations
Signs and Symptoms
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Primary Dysautonomias
Autonomic Nervous System Diseases processed this record on March 24, 2017