Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging
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ClinicalTrials.gov Identifier: NCT00579618
Recruitment Status :
First Posted : December 24, 2007
Last Update Posted : July 31, 2017
Memorial Sloan Kettering Cancer Center
Susan G. Komen Breast Cancer Foundation
Gurwin Jewish Nursing & Rehabilitation Center
Hebrew Home at Riverdale
Jewish Home & Hospital Lifecare System
Margaret Tietz Center
Metropolitan Jewish Health System
Northern Services Group
Parker Jewish Institute
Lenox Hill Neighborhood House
JASA at Temple Emanuel of Parkchester Senior Center
The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.
Condition or disease
Non-cancer Affected Volunteers
Other: Saliva or Blood samples
This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.
obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly. [ Time Frame: conclusion of the study ]
Secondary Outcome Measures :
samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2. [ Time Frame: conclusion of the study ]
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Ages Eligible for Study:
60 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Nursing homes, senior centers, health fairs or other community organizations.
Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
Subjects will self-identify religion and country of origin of grandparents.
Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.
Subjects with mental impairment will be excluded from this study.