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Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00579618
First Posted: December 24, 2007
Last Update Posted: July 31, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Susan G. Komen Breast Cancer Foundation
Beth Abraham
Gurwin Jewish Nursing & Rehabilitation Center
Hebrew Home for the Aged
Jewish Home & Hospital Lifecare System
Margaret Tietz Center
Metropolitan Jewish Health System
Northern Services Group
Parker Jewish Institute
Lenox Hill Neighborhood House
JASA at Temple Emanuel of Parkchester Senior Center
Van Cortlandt Village Senior Center
Information provided by (Responsible Party):
Memorial Sloan Kettering Cancer Center
  Purpose
The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.

Condition Intervention
Non-cancer Affected Volunteers Other: Saliva or Blood samples

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging

Further study details as provided by Memorial Sloan Kettering Cancer Center:

Primary Outcome Measures:
  • obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly. [ Time Frame: conclusion of the study ]

Secondary Outcome Measures:
  • samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2. [ Time Frame: conclusion of the study ]

Biospecimen Retention:   Samples With DNA
Saliva or blood samples

Enrollment: 53
Actual Study Start Date: September 2006
Study Completion Date: July 2017
Primary Completion Date: July 2017 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: Saliva or Blood samples
    Extracting sample of saliva or blood only once.
Detailed Description:
This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Nursing homes, senior centers, health fairs or other community organizations.
Criteria

Inclusion Criteria:

  • Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
  • Subjects will self-identify religion and country of origin of grandparents.
  • Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.

Exclusion Criteria:

  • Subjects with mental impairment will be excluded from this study.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00579618


Locations
United States, New York
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Sponsors and Collaborators
Memorial Sloan Kettering Cancer Center
Susan G. Komen Breast Cancer Foundation
Beth Abraham
Gurwin Jewish Nursing & Rehabilitation Center
Hebrew Home for the Aged
Jewish Home & Hospital Lifecare System
Margaret Tietz Center
Metropolitan Jewish Health System
Northern Services Group
Parker Jewish Institute
Lenox Hill Neighborhood House
JASA at Temple Emanuel of Parkchester Senior Center
Van Cortlandt Village Senior Center
Investigators
Principal Investigator: Kenneth Offit, MD, MPH Memorial Sloan Kettering Cancer Center
  More Information

Additional Information:
Responsible Party: Memorial Sloan Kettering Cancer Center
ClinicalTrials.gov Identifier: NCT00579618     History of Changes
Other Study ID Numbers: 06-102
First Submitted: December 20, 2007
First Posted: December 24, 2007
Last Update Posted: July 31, 2017
Last Verified: July 2017

Keywords provided by Memorial Sloan Kettering Cancer Center:
non-cancer affected volunteers
aged 60 years or older