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Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Pressure Support Ventilation (PSV), Neurally Adjusted Ventilatory Assist (NAVA) and Controlled by Patient

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00576771
Recruitment Status : Completed
First Posted : December 19, 2007
Last Update Posted : April 28, 2015
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital

Brief Summary:
The investigators' aim is to study the effect of pressure support ventilation versus neurally adjusted assist (NAVA) and controlled by patient in mechanically ventilated ALI/ARDS subjects.

Condition or disease Intervention/treatment
ALI/ARDS Patients Procedure: PSV Procedure: NAVA Procedure: patient-controlled

Detailed Description:
In this study, PSV is compared with NAVA and assisted mechanically ventilation controlled by patient through a button. Inclusion criteria are: assisted mechanically ventilated ALI/ARDS patients.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Different Assisted Mechanical Ventilation in ALI/ARDS Patients: PSV, NAVA and Controlled by Patient
Study Start Date : August 2013
Primary Completion Date : November 2014
Study Completion Date : November 2014

Arm Intervention/treatment
Experimental: 1

ALI/ARDS patients

evaluated the effect of PSV, NAVA and assisted controlled mechanical ventilation by patient through a button

Procedure: PSV
Pressure Support Ventilation
Procedure: NAVA
Neurally Adjusted Ventilatory Assist
Procedure: patient-controlled
assisted controlled MV through a button

Primary Outcome Measures :
  1. Respiratory mechanics work of breathing,end expiratory lung volume, gas exchange, dead space, patient's comfort level [ Time Frame: 30 minutes ]

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ALI/ARDS patients

Exclusion Criteria:

  • Haemodynamic instability
  • Barotrauma
  • COPD

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00576771

Policlinico Hospital
Milan, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Principal Investigator: Davide Chiumello, MD Policlinico Hospital

Responsible Party: Davide Chiumello, MD, Policlinico Hospital Identifier: NCT00576771     History of Changes
Other Study ID Numbers: 222222
First Posted: December 19, 2007    Key Record Dates
Last Update Posted: April 28, 2015
Last Verified: April 2015

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Lung Injury