Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension
The aim of the present study is to identify changes in the cardiovascular system in patients with pulmonary hypertension (PH) by magnetic resonance imaging (MRI). MRI is accepted as golden standard method for the evaluation of left and right ventricular morphology and function.
All patients who showed elevated pulmonary pressure in the right heart catheter investigation are assigned to MRI. Parameters derived from MRI are included in the clinical and therapeutic decisions. Well established as well as new MRI parameters are evaluated and compared to the results of right heart catheter. Further age-matched controls without known cardiac or pulmonary disease are investigated by native MRI.
|Pulmonary Hypertension Ventricular Function MR Phase Contrast Velocity Imaging Late Enhancement Patterns|
|Official Title:||Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension|
- right ventricular function [ Time Frame: at the MRI investigation ]right ventricular end-diastolic volume (EDV), right ventricular end-systolic volume (ESV), right ventricular stroke volume (SV), right ventricular ejection fraction (EF), right ventricular cardiac output (CO), right ventricular muscle mass (RVMM)
|Study Start Date:||December 2006|
|Study Completion Date:||December 2013|
|Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
Patients with suspected, latent or manifest pulmonary hypertension
Controls without history of cardiac or pulmonary diseases
Patients with suspected, latent and manifest PH and controls are investigated by MRI according to the following protocol in breathhold or free breathing (depending on the patients' breath-hold abilities). In case of elevated Creatinin values, no contrast agent is applied.
- Planning of cardiac views: Planning of 2-chamber view, short axes view and 4-chamber view.
- Morphological overview: Transversal and coronal Haste images
- Left and right heart functional and valve evaluation: Cine 2-chamber imaging, Multi-slice cine 4-chamber imaging, Cine Left and Right ventricular outflow tract imaging and Multi-slice cine short axes imaging covering the left and right ventricle for evaluation of EDV, ESV, SV, EF, CO and muscle mass.
- Phase Contrast Imaging: Flow measurements in the aorta, the pulmonary artery and the heart.
- Perfusion measurement.
- Late enhancement measurement: Multi-slice short axes view, multi-slice 2-chamber view and multi-slice 4-chamber view.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00575692
|Medical Unitersity Graz, University Clinic of Internal Medicine, Department of Pulmonology|
|Graz, Stmk., Austria, 8036|
|Principal Investigator:||Gabor Kovacs, MD||Medical Unitersity Graz, University Clinic of Internal Medicine, Department of Pulmonology|
|Principal Investigator:||Ursula Reiter, PhD||Medical Unitersity Graz, University Clinic of Radiology, Department of General Radiological Diagnostics|
|Principal Investigator:||Gert Reiter, PhD||Siemens Medical Austria|
|Principal Investigator:||HOrst Olschewski, M.D.||Medical University of Graz|