Pelvic Angiography in Non-Responders to Phosphodiesterase-5 Inhibitors (PANPI)
The specific aim of this pilot study is to describe the angiographic prevalence and pattern of internal pudendal artery (and associated inflow vessel) atherosclerosis in patients with erectile dysfunction who are non-responsive to PDE-5 inhibitors (i.e., Viagra) who are referred for clinically-indicated cardiac catheterization.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Pelvic Angiography in Non-Responders to Phosphodiesterase-5 Inhibitors (PANPI)|
- Distal aortography with iliofemoral run-off will be performed to evaluate disease in the common and internal iliac arteries. [ Time Frame: During Procedural Cath ] [ Designated as safety issue: No ]
- Selective angiography of the internal pudendal artery (and accessory pudendal artery if present) will be performed bilaterally. [ Time Frame: During Procedural Cath ] [ Designated as safety issue: No ]
- Intra-arterial nitroglycerin (or papaverine or tolazoline if nitroglycerin is contraindicated) will be used to facilitate angiographic visualization of the internal pudendal and penile arteries. [ Time Frame: During Procedural Cath ] [ Designated as safety issue: No ]
|Study Start Date:||August 2005|
|Study Completion Date:||March 2008|
The specific aim of this study is to determine if the deep penile arteries can be seen angiographically from the iliac arteries to delineate penile vasculature. Significant obstructive atherosclerotic disease of the deep penile arteries may be present in impotent males. The etiology of erectile dysfunction is multifactorial and may involve vascular disease, endocrine disorders, neurologic disease, prescription medications, psychological issues and/or trauma in any given patient. Vascular disease in patients with erectile dysfunction may be due to trauma, congenital anomalies, or atherosclerosis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00574184
|Principal Investigator:||Jason Rogers, MD||University of California, Davis|