Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
|ClinicalTrials.gov Identifier: NCT00573118|
Recruitment Status : Unknown
Verified December 2007 by Tel-Aviv Sourasky Medical Center.
Recruitment status was: Active, not recruiting
First Posted : December 13, 2007
Last Update Posted : December 13, 2007
Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia.
We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.
|Condition or disease|
|Pregnancy Complications Preeclampsia Placental Abruption Intrauterine Fetal Growth Restriction Intrauterine Fetal Death|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Observational Model:||Case Control|
|Official Title:||A Retrospective Analysis of Possible Association Between Severe Pregnancy Complications and Elevated Factor VIII Plasma Activity.|
|Study Start Date :||January 2000|
|Estimated Study Completion Date :||January 2008|
The study group included 49 patients with a previous history of one or more of the following pregnancy complications: preeclampsia (n = 17), severe IUGR (n = 13), IUFD (n = 14) or placental abruption (n = 5).
The control group included 49 healthy women who delivered during the study period, who did not smoke during pregnancy and in whom pregnancy and delivery were uneventful
- prevalenc of elevated factor VIII [ Time Frame: RETROSPECTIVE ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00573118
|Tel Avis sourasky medical center|
|Tel Aviv, Israel, 64239|
|Principal Investigator:||Eli Rimon, MD||Tel Aviv medical center,Israel|