Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00572871
Recruitment Status : Completed
First Posted : December 13, 2007
Last Update Posted : October 4, 2016
Information provided by (Responsible Party):
University of Missouri-Columbia

Brief Summary:
We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

Condition or disease Intervention/treatment
Osteoporosis Osteopenia Other: plyometric exercise Other: resistance exercise Other: No exercise

Detailed Description:
Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.

Study Type : Observational
Actual Enrollment : 12 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise
Study Start Date : December 2007
Actual Primary Completion Date : December 2009
Actual Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort Intervention/treatment
Exercise after fasting
Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions after a 10-hour fast
Other: resistance exercise
single bout of resistance exercise
No exercise
Will complete a ten-hour fast but do no exercise
Other: No exercise
Will not do any exercise
Exercise after snack
Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions 2 hours following a 500 calorie nutritional supplement
Other: plyometric exercise
single bout of plyometric exercise

Primary Outcome Measures :
  1. serum bone turnover markers [ Time Frame: 24 hours ]

Secondary Outcome Measures :
  1. serum hormones regulating bone turnover [ Time Frame: 24 hours ]

Biospecimen Retention:   Samples Without DNA
serum plasma

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Male participants apparently healthy and non-sedentary free of disease that affects bone and not have used or currently use any medication that affects bone.

Inclusion Criteria:

  • Male
  • No symptoms of disease
  • Non-sedentary
  • Age 25-65

Exclusion Criteria:

  • Medications or supplements that affect bone metabolism or prevent exercise
  • Previous or current medical condition affecting bone health, including osteoporosis.
  • Cardiovascular disease
  • Metallic implants affecting accuracy of bone density scan
  • Current smoker
  • Current participation in high-intensity jumping or resistance exercise in the last 3 months.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00572871

Sponsors and Collaborators
University of Missouri-Columbia
Principal Investigator: Pamela S Hinton, Ph.D. University of Missouri-Columbia

Responsible Party: University of Missouri-Columbia Identifier: NCT00572871     History of Changes
Other Study ID Numbers: 1097239
65438 ( Other Identifier: University of Missouri )
First Posted: December 13, 2007    Key Record Dates
Last Update Posted: October 4, 2016
Last Verified: September 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases