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Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

This study has been completed.
Information provided by (Responsible Party):
University of Missouri-Columbia Identifier:
First received: December 12, 2007
Last updated: September 30, 2016
Last verified: September 2016
We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

Condition Intervention
Osteoporosis Osteopenia Other: plyometric exercise Other: resistance exercise Other: No exercise

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

Resource links provided by NLM:

Further study details as provided by University of Missouri-Columbia:

Primary Outcome Measures:
  • serum bone turnover markers [ Time Frame: 24 hours ]

Secondary Outcome Measures:
  • serum hormones regulating bone turnover [ Time Frame: 24 hours ]

Biospecimen Retention:   Samples Without DNA
serum plasma

Enrollment: 12
Study Start Date: December 2007
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Exercise after fasting
Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions after a 10-hour fast
Other: resistance exercise
single bout of resistance exercise
No exercise
Will complete a ten-hour fast but do no exercise
Other: No exercise
Will not do any exercise
Exercise after snack
Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions 2 hours following a 500 calorie nutritional supplement
Other: plyometric exercise
single bout of plyometric exercise

Detailed Description:
Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.

Ages Eligible for Study:   25 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Male participants apparently healthy and non-sedentary free of disease that affects bone and not have used or currently use any medication that affects bone.

Inclusion Criteria:

  • Male
  • No symptoms of disease
  • Non-sedentary
  • Age 25-65

Exclusion Criteria:

  • Medications or supplements that affect bone metabolism or prevent exercise
  • Previous or current medical condition affecting bone health, including osteoporosis.
  • Cardiovascular disease
  • Metallic implants affecting accuracy of bone density scan
  • Current smoker
  • Current participation in high-intensity jumping or resistance exercise in the last 3 months.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00572871

Sponsors and Collaborators
University of Missouri-Columbia
Principal Investigator: Pamela S Hinton, Ph.D. University of Missouri-Columbia
  More Information

Responsible Party: University of Missouri-Columbia Identifier: NCT00572871     History of Changes
Other Study ID Numbers: 1097239
65438 ( Other Identifier: University of Missouri )
Study First Received: December 12, 2007
Last Updated: September 30, 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases processed this record on September 19, 2017