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Oestrogen Withdrawal in Hypopituitary Women

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00572390
First Posted: December 13, 2007
Last Update Posted: December 13, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Aarhus
  Purpose
By exploring hormonal status in hypopituitary women during oestrogen treatment and without estrogen substitution the influence on sexhormones and organ function is estimated.

Condition Intervention
Hypopituitarism Drug: oestrogen

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Oestrogen Withdrawal in Hypopituitary Women

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • androgens, IGF-I, body composition, liver enzymes, [ Time Frame: 1 month ]

Secondary Outcome Measures:
  • Grehlin, adiponection, leptin [ Time Frame: 1 month ]

Enrollment: 38
Study Start Date: January 2001
Study Completion Date: February 2002
Arms Assigned Interventions
Placebo Comparator: 1
No oestrogen treatment
Drug: oestrogen
Cyclic oestrogen substitution therapy
Experimental: 2
Oestrogen treatment
Drug: oestrogen
Cyclic oestrogen substitution therapy

Detailed Description:
38 hypopituitary women were examinined twice. During oestrogen treatment and after 1 month estrogen withdrawal. A control group of healthy women were examined once.Antropometric data and hormonal parameters were collected.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Hypopituitarism
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00572390


Locations
Denmark
Århus Universityhospital
Århus, Denmark, dk-8000
Sponsors and Collaborators
University of Aarhus
Investigators
Principal Investigator: Jens J Christiansen, PhD Århus Universityhospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jens Sandahl Christiansen, Århus universityhospital
ClinicalTrials.gov Identifier: NCT00572390     History of Changes
Other Study ID Numbers: oestrogen withdrawal
1999/4644
First Submitted: December 11, 2007
First Posted: December 13, 2007
Last Update Posted: December 13, 2007
Last Verified: December 2007

Additional relevant MeSH terms:
Hypopituitarism
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Endocrine System Diseases
Estrogens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs