Oestrogen Withdrawal in Hypopituitary Women

This study has been completed.
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
First received: December 11, 2007
Last updated: December 12, 2007
Last verified: December 2007
By exploring hormonal status in hypopituitary women during oestrogen treatment and without estrogen substitution the influence on sexhormones and organ function is estimated.

Condition Intervention
Drug: oestrogen

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Oestrogen Withdrawal in Hypopituitary Women

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • androgens, IGF-I, body composition, liver enzymes, [ Time Frame: 1 month ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Grehlin, adiponection, leptin [ Time Frame: 1 month ] [ Designated as safety issue: No ]

Enrollment: 38
Study Start Date: January 2001
Study Completion Date: February 2002
Arms Assigned Interventions
Placebo Comparator: 1
No oestrogen treatment
Drug: oestrogen
Cyclic oestrogen substitution therapy
Experimental: 2
Oestrogen treatment
Drug: oestrogen
Cyclic oestrogen substitution therapy

Detailed Description:
38 hypopituitary women were examinined twice. During oestrogen treatment and after 1 month estrogen withdrawal. A control group of healthy women were examined once.Antropometric data and hormonal parameters were collected.

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Hypopituitarism
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00572390

Århus Universityhospital
Århus, Denmark, dk-8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Jens J Christiansen, PhD Århus Universityhospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jens Sandahl Christiansen, Århus universityhospital
ClinicalTrials.gov Identifier: NCT00572390     History of Changes
Other Study ID Numbers: oestrogen withdrawal  1999/4644 
Study First Received: December 11, 2007
Last Updated: December 12, 2007
Health Authority: Denmark: Danish Dataprotection Agency

Additional relevant MeSH terms:
Brain Diseases
Central Nervous System Diseases
Endocrine System Diseases
Hypothalamic Diseases
Nervous System Diseases
Pituitary Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 30, 2016