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Oestrogen Withdrawal in Hypopituitary Women

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ClinicalTrials.gov Identifier: NCT00572390
Recruitment Status : Completed
First Posted : December 13, 2007
Last Update Posted : December 13, 2007
Information provided by:
University of Aarhus

Brief Summary:
By exploring hormonal status in hypopituitary women during oestrogen treatment and without estrogen substitution the influence on sexhormones and organ function is estimated.

Condition or disease Intervention/treatment
Hypopituitarism Drug: oestrogen

Detailed Description:
38 hypopituitary women were examinined twice. During oestrogen treatment and after 1 month estrogen withdrawal. A control group of healthy women were examined once.Antropometric data and hormonal parameters were collected.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 38 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Oestrogen Withdrawal in Hypopituitary Women
Study Start Date : January 2001
Study Completion Date : February 2002

Arm Intervention/treatment
Placebo Comparator: 1
No oestrogen treatment
Drug: oestrogen
Cyclic oestrogen substitution therapy
Experimental: 2
Oestrogen treatment
Drug: oestrogen
Cyclic oestrogen substitution therapy

Primary Outcome Measures :
  1. androgens, IGF-I, body composition, liver enzymes, [ Time Frame: 1 month ]

Secondary Outcome Measures :
  1. Grehlin, adiponection, leptin [ Time Frame: 1 month ]

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Hypopituitarism

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00572390

Århus Universityhospital
Århus, Denmark, dk-8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Jens J Christiansen, PhD Århus Universityhospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jens Sandahl Christiansen, Århus universityhospital
ClinicalTrials.gov Identifier: NCT00572390     History of Changes
Other Study ID Numbers: oestrogen withdrawal
First Posted: December 13, 2007    Key Record Dates
Last Update Posted: December 13, 2007
Last Verified: December 2007

Additional relevant MeSH terms:
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Endocrine System Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs