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Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt (VarenSmoke)

This study has been withdrawn prior to enrollment.
Information provided by:
New York University School of Medicine Identifier:
First received: December 11, 2007
Last updated: April 8, 2015
Last verified: April 2015
Study of varenicline 2.0 mg/day treatment for 2 weeks with smoking test done in laboratory on Day 8 and a 1 week quit attempt from Day 8-14.

Condition Intervention Phase
Nicotine Dependence Drug: varencline Drug: placebo Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Official Title: Placebo-controlled Study of Varenicline Effects on Nicotine Withdrawal Followed by a Test of Smoking Topography, Reward, and Reinforcement

Resource links provided by NLM:

Further study details as provided by New York University School of Medicine:

Primary Outcome Measures:
  • Smoking reward [ Time Frame: laboratory test ]

Secondary Outcome Measures:
  • 1 week abstinence induced craving and reward [ Time Frame: Day 8, 9, 11 and 14 questionaires ]

Enrollment: 0
Study Start Date: September 2007
Arms Assigned Interventions
Active Comparator: 1
Drug: varencline
2.0 mg/day varencline (1.0 mg BID)
Other Name: Chantix
Placebo Comparator: 2
Drug: placebo
matching placebo


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • At least 10 cigarettes/day
  • Interest in quitting smoking
  • Willgness to comply with overnight smoking abbstiennce period followed by lab smoking test

Exclusion Criteria:

  • Pregnancy
  • Axis I psychiatric disorder which require treatment with psychoactive medication and would make study compliance difficult.
  • Clinically significant medical condition in opinion of study clinician
  • Drug or alcohol dependence inlast 12 months
  • Use of other smoking cessation medications ot treatment progams in last 2 months
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Please refer to this study by its identifier: NCT00571805

United States, New York
VA New York Harbor Healthcare System, MHAD clinic
New York, New York, United States, 10010
Sponsors and Collaborators
New York University School of Medicine
Principal Investigator: Malcolm Reid, PhD New York University School of Medicine
  More Information

Responsible Party: Malcolm S. Reid, PhD, New York University School of Medicine Identifier: NCT00571805     History of Changes
Other Study ID Numbers: Varenicline/Smoking
Study First Received: December 11, 2007
Last Updated: April 8, 2015

Keywords provided by New York University School of Medicine:

Additional relevant MeSH terms:
Tobacco Use Disorder
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Nicotinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs processed this record on September 19, 2017