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Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma

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ClinicalTrials.gov Identifier: NCT00568906
Recruitment Status : Unknown
Verified July 2010 by Stanford University.
Recruitment status was:  Recruiting
First Posted : December 6, 2007
Last Update Posted : July 7, 2010
Information provided by:
Stanford University

Brief Summary:
This study will investigate gene expression profiles in normal human lung tissue, lung carcinoma and metastatic tumor to the lung. The expression of up to 20,000 genes in a given lung tissue sample will be examined by cDNA microarray analysis and compared to normal lung tissue. In addition, we hope to identify a particular subset of lung cancer cells with an enhanced capacity for proliferation and self-renewal , analogous to the stem cells recently identified for certain types of leukemia, breast cancer and brain tumors.

Condition or disease
Carcinoma, Giant Cell Carcinoma, Non-Small-Cell Lung Lung Cancer

Study Type : Observational
Estimated Enrollment : 150 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma
Study Start Date : February 2002
Estimated Primary Completion Date : November 2010
Estimated Study Completion Date : June 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Biospecimen Retention:   Samples With DNA
Lung tissue or pleural fluid.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who agree to participate in this study will be those who are undergoing wedge resection, lobectomy on pneumonectomy for clinically diagnosed lung carcinoma or metastatic tumors to the lung, or who are undergoing therapeutic or diagnostic thoracentesis for malignant pleural effusion.

Inclusion Criteria:Adults with non small cell lung cancer

Exclusion Criteria:NA

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00568906

Contact: Susan Jacobs, RN (650) 725-8082 ssjpulm@stanford.edu

United States, California
Stanford University School of Medicine Recruiting
Stanford, California, United States, 94305
Contact: Susan Jacobs, RN    650-725-8082    ssjpulm@stanford.edu   
Contact: Cancer Clinical Trials Office    (650) 498-7061      
Principal Investigator: Glenn D. Rosen         
Sub-Investigator: Laurie Elizabeth Ailles         
Sub-Investigator: Walter B Cannon         
Sub-Investigator: Dr Jessica S. Donington         
Sub-Investigator: Cathy Shachaf         
Sub-Investigator: Heather A. Wakelee         
Sub-Investigator: Irving L. Weissman M.D.         
Sub-Investigator: Richard I Whyte         
Sub-Investigator: Tze-Ming Chen         
Principal Investigator: Daya Upadhyay         
Sponsors and Collaborators
Stanford University
Principal Investigator: Daya Upadhyay Stanford University
Principal Investigator: Glenn D. Rosen Stanford University

Responsible Party: Glenn D. Rosen, Stanford University School of Medicine
ClinicalTrials.gov Identifier: NCT00568906     History of Changes
Other Study ID Numbers: SU-11062007-807
First Posted: December 6, 2007    Key Record Dates
Last Update Posted: July 7, 2010
Last Verified: July 2010

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Carcinoma, Giant Cell
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms