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Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00568906
Recruitment Status : Terminated
First Posted : December 6, 2007
Last Update Posted : May 2, 2019
Sponsor:
Information provided by (Responsible Party):
Stanford University

Study Description
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Brief Summary:
This study will help us understand the gene expression profiles of lung cancer. We will identify genes related to lung cancer development, their growth and metastasis to the lung. In addition, we will examine the role nicotine in the development and progression of lung tumors of smokers, ex-smokers, non-smokers on supplemental nicotine and non smokers with no exposure to nicotine.

Condition or disease
Carcinoma, Giant Cell Carcinoma, Non-Small-Cell Lung Lung Cancer

Study Design
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Study Type : Observational
Actual Enrollment : 129 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma
Study Start Date : February 2002
Actual Primary Completion Date : November 30, 2010
Actual Study Completion Date : October 2011

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Groups and Cohorts
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Outcome Measures
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Primary Outcome Measures :
  1. identify genes related to lung cancer development, their growth and metastasis to the lung. [ Time Frame: day one ]

Biospecimen Retention:   Samples With DNA
Lung tissue or pleural fluid.

Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who agree to participate in this study will be those who are undergoing wedge resection, lobectomy on pneumonectomy for clinically diagnosed lung carcinoma or metastatic tumors to the lung, or who are undergoing therapeutic or diagnostic thoracentesis for malignant pleural effusion.
Criteria
Inclusion Criteria:Adults with non small cell lung cancer Exclusion Criteria:NA
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00568906


Locations
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United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Investigators
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Principal Investigator: Daya Upadhyay Stanford University
Principal Investigator: Glenn D. Rosen Stanford University
More Information
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Responsible Party: Stanford University
ClinicalTrials.gov Identifier: NCT00568906    
Other Study ID Numbers: LUN0011
76094 ( Other Identifier: Stanford University Alternate IRB Approval Number )
SU-11062007-807 ( Other Identifier: Stanford University )
12472 ( Other Identifier: Stanford IRB )
First Posted: December 6, 2007    Key Record Dates
Last Update Posted: May 2, 2019
Last Verified: April 2019
Additional relevant MeSH terms:
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Carcinoma
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Carcinoma, Giant Cell
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
 Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms