Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.

Verified July 2010 by Stanford University.
Recruitment status was: Recruiting

Sponsor:

ClinicalTrials.gov Identifier:

NCT00568906

First Posted: December 6, 2007

Last Update Posted: July 7, 2010

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.

Collaborator:

TRDRP

Information provided by:

Stanford University

Purpose

This study will investigate gene expression profiles in normal human lung tissue, lung carcinoma and metastatic tumor to the lung. The expression of up to 20,000 genes in a given lung tissue sample will be examined by cDNA microarray analysis and compared to normal lung tissue. In addition, we hope to identify a particular subset of lung cancer cells with an enhanced capacity for proliferation and self-renewal , analogous to the stem cells recently identified for certain types of leukemia, breast cancer and brain tumors.

Condition
Carcinoma, Giant Cell Carcinoma, Non-Small-Cell Lung Lung Cancer


Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Prospective
Official Title:	Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma

Resource links provided by NLM:

Genetics Home Reference related topics: lung cancer

MedlinePlus related topics: Genes and Gene Therapy Lung Cancer

U.S. FDA Resources

Further study details as provided by Stanford University:

Biospecimen Retention: Samples With DNA

Lung tissue or pleural fluid.


Estimated Enrollment:	150
Study Start Date:	February 2002
Estimated Study Completion Date:	June 2011
Estimated Primary Completion Date:	November 2010 (Final data collection date for primary outcome measure)

Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:	18 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients who agree to participate in this study will be those who are undergoing wedge resection, lobectomy on pneumonectomy for clinically diagnosed lung carcinoma or metastatic tumors to the lung, or who are undergoing therapeutic or diagnostic thoracentesis for malignant pleural effusion.

Criteria

Inclusion Criteria:Adults with non small cell lung cancer

Exclusion Criteria:NA

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00568906

Contacts


Contact: Susan Jacobs, RN	(650) 725-8082	ssjpulm@stanford.edu

Locations


United States, California
Stanford University School of Medicine	Recruiting
Stanford, California, United States, 94305
Contact: Susan Jacobs, RN 650-725-8082 ssjpulm@stanford.edu
Contact: Cancer Clinical Trials Office (650) 498-7061
Principal Investigator: Glenn D. Rosen
Sub-Investigator: Laurie Elizabeth Ailles
Sub-Investigator: Walter B Cannon
Sub-Investigator: Dr Jessica S. Donington
Sub-Investigator: Cathy Shachaf
Sub-Investigator: Heather A. Wakelee
Sub-Investigator: Irving L. Weissman M.D.
Sub-Investigator: Richard I Whyte
Sub-Investigator: Tze-Ming Chen
Principal Investigator: Daya Upadhyay

Sponsors and Collaborators

Stanford University

TRDRP

Investigators


Principal Investigator:	Daya Upadhyay	Stanford University
Principal Investigator:	Glenn D. Rosen	Stanford University

More Information


Responsible Party:	Glenn D. Rosen, Stanford University School of Medicine
ClinicalTrials.gov Identifier:	NCT00568906 History of Changes
Other Study ID Numbers:	SU-11062007-807 76094 LUN0011
First Submitted:	December 4, 2007
First Posted:	December 6, 2007
Last Update Posted:	July 7, 2010
Last Verified:	July 2010

Additional relevant MeSH terms:


Carcinoma Lung Neoplasms Carcinoma, Non-Small-Cell Lung Carcinoma, Giant Cell Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms	Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Lung Diseases Respiratory Tract Diseases Carcinoma, Bronchogenic Bronchial Neoplasms

To Top