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Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival & Frozen Tissue Sample

This study is currently recruiting participants.
Verified April 2017 by Stanford University
Sponsor:
ClinicalTrials.gov Identifier:
NCT00568438
First Posted: December 6, 2007
Last Update Posted: April 26, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Stanford University
  Purpose
The goal of this study is to study NIS expression in benign and malignant breast and thyroid samples using archival formalin-fixed paraffin-embedded tissue sections.

Condition
Breast Cancer Stomach Neoplasms Salivary Gland Neoplasms Thyroid Cancer

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival and Frozen Human Tissue Samples

Resource links provided by NLM:


Further study details as provided by Stanford University:

Biospecimen Retention:   Samples Without DNA
Cases will be identified from clinic patient medical records and linked to pathology reports. The surgical pathology record number will thus be obtained and used to retrieve the archival blocks and slides. Approximately three representative blocks will be selected and 4-6 four micron thick sections will be cut on a microtome. Cases with limited archived diagnostic material will not be selected nor blocks where there is little materials.

Estimated Enrollment: 300
Study Start Date: October 2000
Estimated Study Completion Date: April 2020
Estimated Primary Completion Date: April 2020 (Final data collection date for primary outcome measure)
Detailed Description:
The objective of the study is to further understanding of proteins that occur in both normal cells and tumor cells and to learn more about certain diseases and potential alternative treatments for these diseases.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Cases will be identified from clinic patient medical records and linked to pathology reports. The surgical pathology record number will thus be obtained and used to retrieve the archival blocks and slides. In addition, all these participants will be clinical patients of the Protocol Director, thus the Physician will always be familiar with the participants.
Criteria

Inclusion Criteria:

  1. Patient must be over the age of 18.
  2. Patients must have benign and malignant breast and thyroid cancer.
  3. Patient mus sign consent form.

Exclusion Criteria:

1. No children will be allowed.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00568438


Locations
United States, California
Stanford University School of Medicine Recruiting
Stanford, California, United States, 94305
Contact: Irene Wapnir    650-736-1353    irene.wapnir@stanford.edu   
Contact: Cancer Clinical Trials Office    (650) 498-7061      
Principal Investigator: Irene L. Wapnir         
Sub-Investigator: Ralph S. Greco MD         
Sub-Investigator: Kent W Nowels         
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Irene L. Wapnir Stanford University
  More Information

Responsible Party: Stanford University
ClinicalTrials.gov Identifier: NCT00568438     History of Changes
Other Study ID Numbers: BRSNSTU0011
75622 ( Other Identifier: Stanford University alternate IRB Number )
11005 ( Other Identifier: Stanford IRB )
First Submitted: December 4, 2007
First Posted: December 6, 2007
Last Update Posted: April 26, 2017
Last Verified: April 2017

Additional relevant MeSH terms:
Neoplasms
Thyroid Neoplasms
Stomach Neoplasms
Salivary Gland Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Head and Neck Neoplasms
Endocrine System Diseases
Thyroid Diseases
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases
Mouth Neoplasms
Mouth Diseases
Stomatognathic Diseases
Salivary Gland Diseases