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Acute Comfort and Blur of Systane and Optive

This study has been completed.
Information provided by (Responsible Party):
Alcon Research Identifier:
First received: December 5, 2007
Last updated: January 31, 2012
Last verified: January 2012
To evaluate drop comfort, acceptability, preference and blur profile between two marketed artificial tears in both dry eye and non-dry eye patient population.

Condition Intervention
Dry Eye
Other: Systane Lubricant Eye Drops
Other: Optive Lubricant Eye Drops

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Acute Comfort and Blurring Profile Evaluation Comparing Systane Lubricant Eye Drops to Optive Lubricant Eye Drops

Resource links provided by NLM:

Further study details as provided by Alcon Research:

Primary Outcome Measures:
  • Visual Blur [ Time Frame: 3 minutes post dose ]
    Visual blur profile is a visual scale ranging from 0 (no blur) to 50 (most blurry). Patients were asked to rate there vision on a specific focal point (an object in the room) through 3 minutes.

Enrollment: 40
Study Start Date: November 2007
Study Completion Date: December 2007
Arms Assigned Interventions
Experimental: Systane Lubricant Eye Drops
Systane Lubricant Eye Drops 1 drop in each eye one time
Other: Systane Lubricant Eye Drops
Systane Lubricant Eye Drops 1 drop each eye once time
Active Comparator: Optive Lubricant Eye Drops
Optive Lubricant Eye Drops 1 drop each one time
Other: Optive Lubricant Eye Drops
Optive Lubricant Eye Drops 1 drop each eye one time


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy, normal eyes OR documented diagnosis of dry eye

Exclusion Criteria:

  • Must not have worn contact lenses for 7 days preceding enrollment
  Contacts and Locations
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Please refer to this study by its identifier: NCT00568386

Sponsors and Collaborators
Alcon Research
Principal Investigator: Mike Christensen Alcon Research
  More Information

Responsible Party: Alcon Research Identifier: NCT00568386     History of Changes
Other Study ID Numbers: M-07-02
Study First Received: December 5, 2007
Results First Received: December 18, 2008
Last Updated: January 31, 2012

Keywords provided by Alcon Research:
Dry eye

Additional relevant MeSH terms:
Lubricant Eye Drops
Ophthalmic Solutions
Pharmaceutical Solutions
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Nasal Decongestants
Vasoconstrictor Agents
Respiratory System Agents processed this record on May 25, 2017