Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

This study has been completed.
Information provided by:
Danish Headache Center Identifier:
First received: November 27, 2007
Last updated: July 31, 2009
Last verified: July 2009
The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

Condition Intervention
Drug: Carbachol

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol

Resource links provided by NLM:

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:
  • Headache response after Carbachol infusion [ Time Frame: 1 day after infusion ] [ Designated as safety issue: No ]

Estimated Enrollment: 12
Study Start Date: August 2007
Study Completion Date: February 2009
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: I Drug: Carbachol
3 microgram per kg bodyweight infused intravenously

Detailed Description:
To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Migraine without aura
  • Weight 50-100 kg

Exclusion Criteria:

  • Other significant diseases
  • Migraine 5 days prior to experiment
  Contacts and Locations
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Please refer to this study by its identifier: NCT00564408

Danish Headache Center
Glostrup, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
Principal Investigator: Henrik Schytz, MD Danish Headache Center
  More Information

Responsible Party: Henrik Schytz/MD, Danish HC Identifier: NCT00564408     History of Changes
Other Study ID Numbers: HC20070049 
Study First Received: November 27, 2007
Last Updated: July 31, 2009
Health Authority: Denmark: Ethics Committee

Additional relevant MeSH terms:
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Analgesics, Non-Narcotic
Autonomic Agents
Cardiotonic Agents
Cholinergic Agents
Cholinergic Agonists
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Protective Agents
Sensory System Agents processed this record on May 22, 2016