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Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2007 by University of Konstanz.
Recruitment status was:  Active, not recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00563888
First Posted: November 26, 2007
Last Update Posted: November 26, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
German Research Foundation
Information provided by:
University of Konstanz
  Purpose
Effective Treatment of PTSD involves talking about the traumatic event in detail.It is unclear how this process influences the sensory-specific trauma network (fear structure)in the traumatized person. The goal of the project is to test the hypothesis that treatment-facilitated recovery does not change the original fear structure but establishes an inhibitory mechanism that depends on verbal activity. An affective visual steady-state paradigm in magnetencephalography (MEG) using positive, aversive and neutral picture stimuli will be used to examine the spatial and temporal pattern of the processing of emotional stimuli. To examine the effects of treatment this paradigm will be used as outcome measure within a randomized controlled trial of Narrative Exposure Therapy and a waiting-list control condition for severely traumatized torture victims.

Condition Intervention
PTSD Behavioral: NET

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims

Further study details as provided by University of Konstanz:

Primary Outcome Measures:
  • PTSD diagnosis and severity score according to the Clinicians Administered PTSD Scale (CAPS) [ Time Frame: 4 & 9 months after completion of treatment ]

Secondary Outcome Measures:
  • steady state visual evoked magnetic fields in response to affective stimuli [ Time Frame: 4 & 9 months after completion of treatment ]

Estimated Enrollment: 30
Study Start Date: January 2007
Estimated Study Completion Date: December 2008
Arms Assigned Interventions
Experimental: A
Narrative Exposure Therapy (NET)
Behavioral: NET
Narrative Exposure Therapy for traumatized survivors of organized violence
No Intervention: B
Waitinglist Control Group

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • experiences of organized violence/torture
  • PTSD diagnosis

Exclusion Criteria:

  • psychotic disorder
  • neurological disease or seizures
  • current drug/alcohol abuse
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00563888


Locations
Germany
University of Konstanz, Department of Psychology
Konstanz, Germany, 78467
Sponsors and Collaborators
University of Konstanz
German Research Foundation
Investigators
Study Director: Claudia Catani, Dr. University of Konstanz
Principal Investigator: Frank Neuner, Prof. University of Konstanz
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00563888     History of Changes
Other Study ID Numbers: SOSS-B6
First Submitted: November 23, 2007
First Posted: November 26, 2007
Last Update Posted: November 26, 2007
Last Verified: November 2007

Keywords provided by University of Konstanz:
PTSD
torture survivors
Narrative Exposure Therapy
trauma-related memory processes
steady state visual evoked fields


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