Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-Study)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2007 by University of Oslo.
Recruitment status was  Recruiting
Information provided by:
University of Oslo Identifier:
First received: November 23, 2007
Last updated: NA
Last verified: November 2007
History: No changes posted
An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.

Condition Intervention
Heart Failure
Cheyne Stokes Respiration
Device: ASV
Other: without Autoset CS2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Open Randomized Study of Patients With Chronic Heart Failure and Cheyne Stokes Respiration Pattern, Treated With ASV. (Adaptive Servo Ventilator).

Resource links provided by NLM:

Further study details as provided by University of Oslo:

Primary Outcome Measures:
  • Ejection fraction (measured with echocardiography) and inflammatory markers [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • 6 minutes walking test Quality of life Changes in cathecolamines Altered frequency of arrythmias [ Time Frame: 3 months ]

Estimated Enrollment: 40
Study Start Date: September 2007
Estimated Study Completion Date: December 2008
Arms Assigned Interventions
Experimental: A
The patients use ASV
Device: ASV
Adaptive servo ventilator
Other Name: AutoSet CS2
Other: without Autoset CS2
without Autoset CS2
Active Comparator: B
Patients without ASV
Other: without Autoset CS2
without Autoset CS2

Detailed Description:

Chronic heart failure (HF) is one of the most important public health problems in cardiovascular medicine.

Several patients with chronic heart failure also has Cheyne Stokes respiration pattern. Earlier studies have shown that this respiration pattern improves with Adaptive servo ventilator. We wish to investigate wether this leads to improved cardiac function.


Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Ejection fraction <40%
  • NYHA class III-IV
  • Optimized therapy with drugs
  • Cheyne stokes respiration pattern > 25% while sleeping
  • Age < 85 years
  • clinical stability the last month before inclusion.

Exclusion Criteria:

  • CABG less then 6 months ago
  • PCI treatment less then 3 months ago
  • Unstable angina pectoris
  • Acute coronary syndrome less then 3 months ago
  • Stroke less then 6 weeks ago
  • Thoracal myopathy
  • Advanced COPD
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00563693

Contact: Arild Hetland, cardiologist +4769860000
Contact: Stian Ross +4769860000

Sykehuset ostfold Fredrikstad Recruiting
Fredrikstad, Norway
Contact: Arild Hetland, cardiologist    +4769860000   
Contact: Stian Ross, dr    +4769860000   
Principal Investigator: Arild Hetland, cardiologist         
Sponsors and Collaborators
University of Oslo
Principal Investigator: Arild Hetland, cardiologist University of Oslo
  More Information

No publications provided Identifier: NCT00563693     History of Changes
Other Study ID Numbers: 1.2007.980
Study First Received: November 23, 2007
Last Updated: November 23, 2007
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by University of Oslo:
heart failure
cheyne stokes respiration
adaptive servo ventilator

Additional relevant MeSH terms:
Cheyne-Stokes Respiration
Heart Failure
Cardiovascular Diseases
Heart Diseases
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms
Signs and Symptoms, Respiratory processed this record on December 01, 2015