Mycophenolate Mofetil for the Prophylaxis of Graft-versus-host Disease in High Risk Allogeneic Stem Cell Transplantation
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ClinicalTrials.gov Identifier: NCT00563589
Recruitment Status : Unknown
Verified July 2010 by Hospital Authority, Hong Kong. Recruitment status was: Recruiting
There is a significant (50-80%) risk of acute graft-versus-host disease(GVHD) and early mortality (30%) associated with high risk stem cell transplantation (SCT) such as that from a matched unrelated donor or HLA-mismatch sibling. Mycophenolate mofetil (MMF) has been shown to be an effective and safe immunosuppressant in the prevention and treatment of rejection after solid organ transplantation. Its role in acute GVHD prophylaxis in high risk SCT will be investigated in this clinical trial.
Condition or disease
Graft vs Host DiseaseHematopoietic Stem Cell Transplantation
Drug: mycophenolate mofetil, methotrexate, cyclosporinDrug: Methotrexate and cyclosporin
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
patients undergoing allogeneic SCT with high risk of acute GVHD, ie. from matched unrelated donor or one HLA-locus mismatch sibling