Study of the Efficacy of Darbepoetin Alfa in the Treatment of Renal Anemia
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|ClinicalTrials.gov Identifier: NCT00563446|
Recruitment Status : Completed
First Posted : November 26, 2007
Last Update Posted : June 16, 2011
Anaemia is a common consequence of chronic renal failure. Darbepoetin alfa is a unique erythropoietic protein that stimulates erythropoiesis by the same mechanism as endogenous erythropietin and conventional recombinant human erythropoietin (rHuEPO). Darbepoetin alfa has been shown to have a serum half-life 3-fold longer than that of rHuEPO, which allows dosing at extended intervals and less frequent injection.
The objective is to evaluate the efficacy and safety of darbepoetin alfa therapy given at an extended once monthly dosing interval in the treatment of renal anaemia in continuous ambulatory peritoneal dialysis.
|Condition or disease||Intervention/treatment||Phase|
|Anemia Kidney Failure, Chronic Peritoneal Dialysis, Continuous Ambulatory||Drug: Darbepoetin alfa||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||16 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Conversion From Once Weekly Recombinant Human Erythropoietin to Once Monthly Darbepoetin Alfa for the Treatment of Renal Anemia in Continuous Ambulatory Peritoneal Dialysis Patients|
|Study Start Date :||July 2005|
|Actual Study Completion Date :||May 2006|
- Hemoglobin level [ Time Frame: Over 6 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00563446
|Princess Margaret Hospital|
|Hong Kong, China|
|Principal Investigator:||Samuel KS Fung, Dr||Division of Nephrology, Medicine & Geriatrics, Princess Margaret Hospital|