Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?
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ClinicalTrials.gov Identifier: NCT00560625
Recruitment Status :
(recruiting subjects did not start.)
Inhaled corticosteroids are largely used in patients with asthma or chronic obstructive lung diseases. The purpose of this study is to determine if the use of inhaled corticosteroids is associated with suppression of endogenous cortisol production, as seen in patients treated with pharmacologic doses of oral or parenteral steroids.
Condition or disease
The normalcy of the hypothalmic-pituitary-adrenal (HPA) axis of enrolled subjects will be assessed by low dose (1mcg) corticotropin (ACTH)stimulation test. Serum cortisol levels will be measured before , 30 minutes and 60 minutes after 1 mcg ACTH intravenous injection.
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
hospital-based respiratory diseases clinic
patients receiving inhaled busedonide or fluticasone at daily dose of 200-800 mcg ' for at least 4 weeks
patients receiving any corticosteroid therapy, except inhaled busedonide or fluticasone.