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Pain Processing in Anxiety and Depression

This study has been completed.
Information provided by (Responsible Party):
Danish Pain Research Center Identifier:
First received: November 16, 2007
Last updated: January 20, 2016
Last verified: August 2009
The purpose of the study is to investigate pain, anxiety and depression in patients with panic anxiety disorders without pain or depression without pain compared with healthy volunteers

Condition Intervention
Other: Observation

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Pain, Anxiety and Depression in Patients With Panic Anxiety Disorders Without Pain or Depression Without Pain Compared With Healthy Volunteers

Resource links provided by NLM:

Further study details as provided by Danish Pain Research Center:

Primary Outcome Measures:
  • Quantitative sensory testing [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Symptom checklist 92 [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Hamilton Depression and Anxiety Rating Scale [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Major Depression Inventory [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • GAD-10 Anxiety Scale [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Health Survey SF-36 [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • McGill Pain Questionnaire [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Sweat test [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Heart rate variability testing [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Coping Strategy Questionnaire [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Pain Catastrophizing Scale [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Pain rating (VAS) [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]
  • Interview [ Time Frame: 3-4 hours ] [ Designated as safety issue: No ]

Enrollment: 71
Study Start Date: November 2007
Study Completion Date: February 2009
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients with panic anxiety disorder without pain
Other: Observation
Patients with depression without pain
Other: Observation
Healthy controls
Other: Observation


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Outpatient clinic Primary care clinic Community sample

Inclusion Criteria:

  • Patients with panic disorder or depression

Exclusion Criteria:

  • Treatment with antidepressants, anticonvulsants or any other pain medication except paracetamol, SSRI and benzodiazepines
  • Serious or unstable medical disease
  • Prior or present diagnosis of mania, bipolar or psychotic disorder, delirium, suicidal, drug and alcohol dependence, severe agitation
  • Patients who cannot cooperate and do not understand Danish
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00560196

Danish Pain Research Center, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
Danish Pain Research Center
Principal Investigator: Lise Gormsen, MD Danish Pain Research Center, Aarhus University Hospital
  More Information

Responsible Party: Danish Pain Research Center Identifier: NCT00560196     History of Changes
Other Study ID Numbers: PAD2007LG 
Study First Received: November 16, 2007
Last Updated: January 20, 2016
Health Authority: Denmark: Danish Dataprotection Agency

Keywords provided by Danish Pain Research Center:
Neuropathic pain
Chronic pain

Additional relevant MeSH terms:
Depressive Disorder
Anxiety Disorders
Behavioral Symptoms
Mood Disorders
Mental Disorders processed this record on October 28, 2016