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Prevention of Acute Mountain Sickness by Intermittent Hypoxia

This study has been completed.
Information provided by:
Heidelberg University Identifier:
First received: November 15, 2007
Last updated: NA
Last verified: November 2007
History: No changes posted

Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective in prevention of acute mountain sickness (AMS).

The aim of this study is to investigate whether intermittent exposure to normobaric hypoxia during sleep is also effective to prevent AMS.

Condition Intervention
Acute Mountain Sickness
Other: Hypoxic Exposure

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: Prevention of Acute Mountain Sickness by Sleeping at Simulated Altitude (Normobaric Hypoxia)

Resource links provided by NLM:

Further study details as provided by Heidelberg University:

Primary Outcome Measures:
  • incidence of acute mountain sickness [ Time Frame: during one night at 4500 m ]

Secondary Outcome Measures:
  • Sleep quality [ Time Frame: during one night at altitude ]
  • ventilatory acclimatization [ Time Frame: during one night at altitude ]

Enrollment: 75
Study Start Date: March 2006
Study Completion Date: July 2007
Arms Assigned Interventions
No Intervention: Normoxia
Sleeping in normoxia for 14 nights prior to one night at 4500 m
Experimental: Hypoxia
Sleeping in normobaric hypoxia for 14 nights at altitudes from 2500 - 3300 m prior to one night at 4500 m
Other: Hypoxic Exposure
Sleeping in normobaric hypoxia for 14 nights at altitudes from 2500 - 3300 m prior to one night at 4500 m


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy

Exclusion Criteria:

  • Altitude exposure above 2000 m 8 weeks prior or during the study
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Please refer to this study by its identifier: NCT00559832

Sports Medicine, University Hospital
Heidelberg, Germany, 69120
Sponsors and Collaborators
Heidelberg University
Principal Investigator: Christoph Dehnert, MD University Hospital Heidelberg
  More Information Identifier: NCT00559832     History of Changes
Other Study ID Numbers: 039/2006
Study First Received: November 15, 2007
Last Updated: November 15, 2007

Keywords provided by Heidelberg University:
acute mountain sickness
intermittent hypoxia

Additional relevant MeSH terms:
Altitude Sickness
Signs and Symptoms, Respiratory
Signs and Symptoms
Respiration Disorders
Respiratory Tract Diseases processed this record on May 22, 2017