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The Effect of Aging and Immobilisation on Muscle

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00559806
First Posted: November 16, 2007
Last Update Posted: November 16, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Bispebjerg Hospital
  Purpose
The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Condition Intervention
Healthy Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Aging and Immobilisation on Muscle

Further study details as provided by Bispebjerg Hospital:

Primary Outcome Measures:
  • muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation [ Time Frame: 2 weeks of immobilisation and 4 weeks of resistance training ]

Secondary Outcome Measures:
  • single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number [ Time Frame: 2 weeks of imm and 4 weeks of resistance training ]

Enrollment: 20
Study Start Date: January 2007
Study Completion Date: May 2007
Arms Assigned Interventions
Experimental: 1
9 healthy elderly males
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
Experimental: 2
11 healthy young males
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion Criteria:

  • Musculoskeletal disorder
  • Diabetes
  • Cardiovascular disease
  • Neurological diseases; or
  • Cognitive disorders
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00559806


Locations
Denmark
Institute of Sports Medicine, Bispebjerg Hospital
Copenhagen, Denmark, 2400-NV
Sponsors and Collaborators
Bispebjerg Hospital
Investigators
Principal Investigator: Charlotte Suetta, MD, PhD Institute of Sports Medicine Copenhagen, Bispebjerg Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00559806     History of Changes
Other Study ID Numbers: KF01-322606
First Submitted: November 15, 2007
First Posted: November 16, 2007
Last Update Posted: November 16, 2007
Last Verified: November 2007

Keywords provided by Bispebjerg Hospital:
immobilisation
aging
resistance training
atrophy
The effect of immobilisation in elderly compared to young individuals