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The Effect of Aging and Immobilisation on Muscle

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ClinicalTrials.gov Identifier: NCT00559806
Recruitment Status : Completed
First Posted : November 16, 2007
Last Update Posted : November 16, 2007
Sponsor:
Information provided by:
Bispebjerg Hospital

Brief Summary:
The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Condition or disease Intervention/treatment Phase
Healthy Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Aging and Immobilisation on Muscle
Study Start Date : January 2007
Actual Study Completion Date : May 2007

Arm Intervention/treatment
Experimental: 1
9 healthy elderly males
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control
Experimental: 2
11 healthy young males
Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training
2 weeks of unilateral whole leg casting (side randomized)followed by 4 weeks of unilateral resistance training. The non-imm side served as a within-subject control



Primary Outcome Measures :
  1. muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation [ Time Frame: 2 weeks of immobilisation and 4 weeks of resistance training ]

Secondary Outcome Measures :
  1. single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number [ Time Frame: 2 weeks of imm and 4 weeks of resistance training ]


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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion Criteria:

  • Musculoskeletal disorder
  • Diabetes
  • Cardiovascular disease
  • Neurological diseases; or
  • Cognitive disorders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00559806


Locations
Denmark
Institute of Sports Medicine, Bispebjerg Hospital
Copenhagen, Denmark, 2400-NV
Sponsors and Collaborators
Bispebjerg Hospital
Investigators
Principal Investigator: Charlotte Suetta, MD, PhD Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

ClinicalTrials.gov Identifier: NCT00559806     History of Changes
Other Study ID Numbers: KF01-322606
First Posted: November 16, 2007    Key Record Dates
Last Update Posted: November 16, 2007
Last Verified: November 2007

Keywords provided by Bispebjerg Hospital:
immobilisation
aging
resistance training
atrophy
The effect of immobilisation in elderly compared to young individuals