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Muscle Function in Elderly Postoperative Patients

This study has been completed.
Information provided by:
Bispebjerg Hospital Identifier:
First received: November 15, 2007
Last updated: NA
Last verified: November 2007
History: No changes posted

During the last decades there has been an increase in the relative proportion and life expectancy of elderly people in the industrialised countries. Consequently the amount of elderly with diseases and disabilities related to aging has increased. It therefore appears paramount to gain a better understanding of how disuse and immobilisation affects neuromuscular properties in the elderly, as well as to identify training regimes that ensures an effective rehabilitation.The population of interest in the present study was elderly individuals with long term hip-osteoarthritis undergoing a hip-replacement operation. The study was divided in two parts, a cross-sectional study and an intervention study.

The cross-sectional study investigated muscle size, maximal muscle strength, specific force, neural drive and explosive muscle force characteristics in elderly individuals who were affected by unilateral prolonged disuse due to hip-osteoarthritis. The data clearly indicated that the side with hip-osteoarthritis was affected by a marked decrease in muscle mass, maximal muscle strength, neural drive and explosive muscle force characteristics compared to the unaffected side.

The intervention study investigated if elderly patients that undergo hip-replacement surgery could benefit from additional training in the early postoperative phase. The data clearly demonstrated that resistance training was an effective and safe way to increase muscle mass, maximal muscle strength, neuromuscular activity, functional performance and decrease the hospitalisation period compared to regimes of conventional rehabilitation regimen or electrical muscle stimulation. Additionally the intervention study demonstrated that resistance training effectively induced marked increases in explosive muscle force characteristics in elderly subjects compared to rehabilitation regimes using electrical muscle stimulation or conventional rehabilitation. Furthermore, the gains in maximal muscle strength and explosive muscle force characteristics were accompanied by significant increases in EMG amplitudes. Furthermore, the demonstration that explosive muscle force capacity of the neuromuscular system remains trainable in elderly recovering from prolonged limb disuse and major surgery may have important implications for future rehabilitation programs, especially when considering the importance of rapid muscle force capacity on postural balance, maximal walking speed and other tasks of daily life actions.

Condition Intervention
Rehabilitation Strategies for Elderly Post-Operative Patients Behavioral: Resistance training Behavioral: Neuromuscular electrical stimulation of the quadriceps muscle Behavioral: Standard rehabilitation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Muscle Function in the Elderly After Hip-Replacement Surgery - Effects of Long Term Disuse and Physical Training

Resource links provided by NLM:

Further study details as provided by Bispebjerg Hospital:

Enrollment: 36
Study Start Date: May 2000
Study Completion Date: December 2003
Arms Assigned Interventions
Experimental: 1
12 weeks of resistance training
Behavioral: Resistance training
12 weeks of resistance training (3/week)
Experimental: 2
12 weeks of neuromuscular electrical stimulation
Behavioral: Neuromuscular electrical stimulation of the quadriceps muscle
12 weeks of neuromuscular electrical stimulation of the quadriceps muscle (1h/day)
12 weeks of standard rehabilitation
Behavioral: Standard rehabilitation
12 weeks of standard physiotherapy exercises (1h/day)


Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age over 60 years
  • Unilateral primary hip replacement due to hip osteoarthritis in patients

Exclusion Criteria:

  • Cardiopulmonary, neurological or cognitive problems
  Contacts and Locations
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Please refer to this study by its identifier: NCT00559780

Institute of Sports Medicine, Bispebjerg Hospital
Copenhagen, Denmark, 2400-NV
Sponsors and Collaborators
Bispebjerg Hospital
Principal Investigator: Charlotte Suetta, MD, PhD Institute of Sports Medicine copenhagen, Bispebjerg Hospital
  More Information Identifier: NCT00559780     History of Changes
Other Study ID Numbers: HKF:01058/00
Study First Received: November 15, 2007
Last Updated: November 15, 2007

Keywords provided by Bispebjerg Hospital:
Resistance training
hip-surgery processed this record on September 21, 2017