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Effects of Fetal, Infant, and Early Childhood Exposures on Adult Cancer Risk in Women

This study has been completed.
National Cancer Institute (NCI)
Information provided by:
National Institutes of Health Clinical Center (CC) Identifier:
First received: November 15, 2007
Last updated: March 7, 2012
Last verified: March 2012

RATIONALE: Gathering information about pregnancy, infancy, and early childhood exposures may help doctors identify cancer risk factors, and may help the study of cancer.

PURPOSE: This natural history study is looking at the effects of fetal, infant, and early childhood exposures on adult cancer risk in women.

Condition Intervention
Breast Cancer Unspecified Adult Solid Tumor, Protocol Specific Other: questionnaire administration Procedure: evaluation of cancer risk factors

Study Type: Observational
Official Title: Fetal, Infant and Early Childhood Antecedents of Cancer in Women: Maternal Cohort Study of the Nurses' Health Studies

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Primary Outcome Measures:
  • Diagnosis of incident cancers and other chronic diseases
  • Mortality

Estimated Enrollment: 128700
Study Start Date: October 2000
Study Completion Date: October 2006
Detailed Description:


  • Determine if fetal, infant, and early childhood exposures are associated with adult cancer risk in women.

OUTLINE: Mothers of nurses complete questionnaires to collect maternal data, such as pregnancy weight gain, diet during pregnancy, maternal pre-eclampsia, gestational diabetes, gestational age at birth, birth weight, and infant feeding practices. Maternal data is linked to other data collected from critical time periods in the nurses's life cycle, such as menarche, first pregnancy, or adult dietary intake.


Ages Eligible for Study:   18 Years to 89 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes


  • Mother of a nurse who is a participant in the Nurses' Health Studies I and II

    • Nurse free of cancer in the year 2000


  • Not specified


  • Not specified
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00559039

United States, Maryland
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
Bethesda, Maryland, United States, 20892-1182
Sponsors and Collaborators
National Institutes of Health Clinical Center (CC)
National Cancer Institute (NCI)
Principal Investigator: Michele R. Forman, PhD M.D. Anderson Cancer Center
  More Information Identifier: NCT00559039     History of Changes
Obsolete Identifiers: NCT00340145
Other Study ID Numbers: 999901015
Study First Received: November 15, 2007
Last Updated: March 7, 2012

Keywords provided by National Institutes of Health Clinical Center (CC):
breast cancer
unspecified adult solid tumor, protocol specific processed this record on August 21, 2017