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Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2008 by Hannover Medical School.
Recruitment status was:  Recruiting
Information provided by:
Hannover Medical School Identifier:
First received: November 14, 2007
Last updated: July 19, 2011
Last verified: September 2008
In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.

Lung Transplantation

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

Resource links provided by NLM:

Further study details as provided by Hannover Medical School:

Biospecimen Retention:   Samples Without DNA
BAL (broncho alveolar lavage) urine

Estimated Enrollment: 60
Study Start Date: March 2008
Estimated Study Completion Date: December 2011
30 patients with stable graft function
30 patients with acute rejection after lung transplantation

Detailed Description:
Goal of the study is the establishment of biomarkers for early diagnosis of acute rejection, followed by a late validation of the paradigm with prospectively collected samples, which will be examined blinded.

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients after lung transplantation

Inclusion Criteria:

  • Patients with stable graft function
  • Patients with acute rejection

Exclusion Criteria:

  • Acute infection
  • BOS
  Contacts and Locations
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Please refer to this study by its identifier: NCT00558597

Contact: Jens Gottlieb, Dr. med. +49-511-5320 ext 3560
Contact: Isabelle Bodmann +49-511-5320 ext 2667

Hannover Medical School Recruiting
Hannover, Germany, 30625
Contact: Jens Gottlieb, Dr. med.    +49-511-5320 ext 3560   
Sub-Investigator: Markus Berkefeld, Dr. med.         
Sponsors and Collaborators
Hannover Medical School
Principal Investigator: Jens Gottlieb, Dr. med. Hannover Medical School
  More Information

Responsible Party: Hannover Medical School, Medical School Identifier: NCT00558597     History of Changes
Other Study ID Numbers: 154
Study First Received: November 14, 2007
Last Updated: July 19, 2011

Keywords provided by Hannover Medical School:
Lung Transplantation processed this record on May 24, 2017