Optimization of Cardiac-MR Protocols

Study Description

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Brief Summary:

The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR images. One of the main problems in cardiac MR investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations with special emphasis on phase-contrast imaging and other cine-techniques.

Condition or disease
Sequence Optimization; Protocol Optimization; Normal Values; Feasibility

Detailed Description:

Time optimized and well organized MR protocols for the cardiac and lung investigations are evaluated on normal subjects with special respect to following topics:

1. Localization: Definition of standardized anatomic imaging planes with special respect to the right ventricle.
2. Morphological imaging: Optimization of spin-echo and gradient-echo sequences for various heart frequencies and breath-hold abilities. Investigation of the effect of various preparation pulses. Optimization of the signal-to-noise ratio for morphological cardiac imaging. Evaluation and optimization of various breathing and breath-hold (with and without navigator) ECG and pulse triggered sequences.
3. Cardiac and lung function: Optimization of gradient-echo sequences for various heart frequencies and breath-hold abilities. Evaluation of pulse-triggered function analysis and optimization of free breathing protocols. Optimization of tagging techniques. Evaluation of the pulsatile flow in lung vessels. Acquisition of age depended normal data of cardiac and lung function.
4. Coronary imaging: Definition of standardized anatomic imaging planes to monitor coronary arteries (single oblique, volume targeted). Optimization of acquisition window with respect to various heart frequencies. Evaluation of the influence of the position of the navigator and tracking factor on image quality. Optimization of a pulse triggered protocol. Evaluation of black-blood coronary imaging and visualization of the lumen and wall of coronary arteries.
5. Phase contrast techniques: Optimization of imaging planes, time resolution and spatial resolution of flow measurements in the heart, in the vessels around the heart, lung vessels and coronary arteries. Evaluation of retrospective and prospective gating with respect to the heart frequency. Evaluation of normal values in 1-dimensional, 2-dimensional and 3-dimensional time resolved flow measurements.
6. Single-Shot Imaging: Evaluation of signal intensity and stability of single shot techniques with and without preparation pulses. Optimization of real-time image acquisition.
7. Parallel acquisition and breath-hold time optimization: Evaluation of impact of echo-sharing and parallel acquisition on image quality. Optimization of short-breath-hold protocols.

Study Design

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Study Type :	Observational
Actual Enrollment :	122 participants
Official Title:	Optimization of Native Cardiac-MR Protocols
Study Start Date :	October 2002
Actual Primary Completion Date :	September 2011
Actual Study Completion Date :	September 2011

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	16 Years and older (Child, Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

healthy volunteers

Criteria

Inclusion Criteria:

• No history of cardiac or pulmonary diseases

Exclusion Criteria:

• MRI exclusion criteria

Contacts and Locations

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Locations

Austria
Medical Unitersity Graz, Allgemeine Radiologische Diagnostik
Graz, Stmk, Austria, 8036

Sponsors and Collaborators

Medical University of Graz

Investigators

Principal Investigator:	Gert Reiter, DI Dr.	Siemens Medical Solutions
Principal Investigator:	Ursula Reiter, DI Dr.	University Hospital Graz

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications of Results:

Reiter G, Reiter U, Bergmann P, Rienmüller R. MR imaging-based port placement planning for totally endoscopic coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2004 Jun;3(2):341-5.

Reiter G, Reiter U, Rienmüller R, Gagarina N, Ryabikin A. On the value of geometry-based models for left ventricular volumetry in magnetic resonance imaging and electron beam tomography: a Bland-Altman analysis. Eur J Radiol. 2004 Nov;52(2):110-8.

Reiter G, Reiter U, Kovacs G, Kainz B, Schmidt K, Maier R, Olschewski H, Rienmueller R. Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure. Circ Cardiovasc Imaging. 2008 Jul;1(1):23-30. doi: 10.1161/CIRCIMAGING.108.780247.

Responsible Party:	Ursula Reiter, PhD, Medical University of Graz
ClinicalTrials.gov Identifier:	NCT00557869 History of Changes
Other Study ID Numbers:	CMR-02-TECH-01
First Posted:	November 14, 2007
Last Update Posted:	December 20, 2011
Last Verified:	December 2011