Use of a Gamma-IFN Assay in Contact Tracing for Tuberculosis in a Low-Incidence, High Immigration Area
Latent Tuberculosis Infection
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Production of Gamma-Interferon by Circulating Lymphocytes Exposed to Antigens Specific of Mycobacterium Tuberculosis: Contribution to the Identification of Latent Tuberculosis Infection in Contact Tracing|
- Correlation between results of TST and IGRA tests and exposure scores [ Time Frame: 2 months after exposure ]
|Study Start Date:||October 2004|
|Study Completion Date:||January 2006|
Setting: A TB clinic in Geneva, Switzerland, a low incidence area for TB with a high immigrant population.
Aim of study: to compare results of an IGRA test (T-SPOT.TB, Oxford Immunotec, UK) and the TST, and their correlation with exposure scores in subjects exposed to cases of contagious TB.
Methods: Prospective study of all contacts screened in our area, and accepting to be included. Simultaneous recording of age, gender, origin, history of recent travels or exposure, BCG vaccination status, infectiousness of index case, 5 different exposure scores, TST, and result of the T-SPOT.TB blood test. Univariate and multivariate analysis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00557765
|Centre antituberculeux; Geneva University Hospital|
|Geneva, Switzerland, 1211|
|Principal Investigator:||Jean-Paul Janssens, M.D.||Centre antituberculeux|