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Serial Changes of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Levels in Patients With Acute Respiratory Distress Syndrome

This study has been completed.
Information provided by:
National Taiwan University Hospital Identifier:
First received: November 12, 2007
Last updated: May 8, 2008
Last verified: May 2008
The purpose of this study is to determine the impact of the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) on etiology and prognosis of acute respiratory distress syndrome (ARDS)

Acute Respiratory Distress Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Serial Changes of sTREM-1 Levels in Patients With Acute Respiratory Distress Syndrome

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • all cause mortality [ Time Frame: 28 days ]
  • Septic or non-septic etiology [ Time Frame: At enrollment ]

Secondary Outcome Measures:
  • CRP, lactate, WBC count, APACHE II score, LIS, SOFA score [ Time Frame: At enrollment ]
  • IL-1 beta, IL-8, TNF-alpha [ Time Frame: serial follow up at Day 1, 3, 5, 7, 14 ]

Biospecimen Retention:   Samples Without DNA

Enrollment: 63
Study Start Date: October 2007
Study Completion Date: March 2008
Detailed Description:
The triggering receptor expressed on myeloid cells-1 (TREM-1), a member of the immunoglobulin superfamily, is upregulated on phagocytic cells in the presence of bacteria or fungi infection and weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form (sTREM-1) in body fluids. The level and serial change of a serum sTREM-1 from cirtical ill patients has been shown to be a good diagnostic and prognostic indicator of ventilation associated pneumonia (VAP) and severe sepsis.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients admitted into ICU of a medical center in Taiwan

Inclusion Criteria:

  • Fulfill clinical diagnosis of ARDS
  • Require mechanical ventilation support

Exclusion Criteria:

  • Pregnant
  • Immunocompromised
  Contacts and Locations
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Please refer to this study by its identifier: NCT00557414

National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Chao-Chi Ho Department of Internal Medicine and Emergency Medicine, National Taiwan University Hospital
  More Information

Responsible Party: Chao-Chi Ho, National Taiwan University Hospital Identifier: NCT00557414     History of Changes
Other Study ID Numbers: 200709060R
Study First Received: November 12, 2007
Last Updated: May 8, 2008

Keywords provided by National Taiwan University Hospital:
acute respiratory distress syndrome
soluble triggering receptor expressed on myeloid cells-1

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury processed this record on April 28, 2017