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Salivary Catecholamines in Aphthous Stomatitis (Canker Sores)

This study has been withdrawn prior to enrollment.
(We are currently modifying the study)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00556686
First Posted: November 12, 2007
Last Update Posted: April 22, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of California, Davis
  Purpose
The purpose of this study is to examine how compounds produced in patients with canker sores affect wound healing.

Condition
Canker Sore

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Salivary Catecholamines in Aphthous Stomatitis

Resource links provided by NLM:


Further study details as provided by University of California, Davis:

Biospecimen Retention:   Samples Without DNA
saliva

Enrollment: 0
Study Start Date: August 2006
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Individuals with a history of canker sores.
2
Individuals with no history of canker sores.

Detailed Description:
The purpose of this study is to determine if salivary catecholamines are elevated in patients with the disease aphthous stomatitis. The results of this study will be combined with those performed in collaboration with a co-Investigator to understand the effects of catecholamines on mucosal wound healing and oral epithelial cell migration.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All subjects will be sampled from the community.
Criteria

Inclusion Criteria:

  • Age 18 or older, both genders
  • History of recurrent aphthous ulcers with 4 or more episodes per year

Exclusion Criteria:

  • History of salivary gland disease including Sjogren's disease, parotitis, and sialolithiasis
  • History of benign or malignant salivary gland tumor
  • History of celiac disease, ulcerative colitis or Crohn's disease
  • Patients on medications that affect salivary flow such as anti-depressants and anti-cholinergic medications
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00556686


Sponsors and Collaborators
University of California, Davis
Investigators
Principal Investigator: Nasim Fazel, MD, DDS University of California, Davis
  More Information

Additional Information:
Responsible Party: University of California, Davis
ClinicalTrials.gov Identifier: NCT00556686     History of Changes
Other Study ID Numbers: 200614581
First Submitted: November 8, 2007
First Posted: November 12, 2007
Last Update Posted: April 22, 2015
Last Verified: April 2015

Additional relevant MeSH terms:
Stomatitis
Stomatitis, Aphthous
Mouth Diseases
Stomatognathic Diseases