Salivary Catecholamines in Aphthous Stomatitis (Canker Sores)

This study has been withdrawn prior to enrollment.
(We are currently modifying the study)
Information provided by (Responsible Party):
University of California, Davis Identifier:
First received: November 8, 2007
Last updated: April 20, 2015
Last verified: April 2015
The purpose of this study is to examine how compounds produced in patients with canker sores affect wound healing.

Canker Sore

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Salivary Catecholamines in Aphthous Stomatitis

Resource links provided by NLM:

Further study details as provided by University of California, Davis:

Biospecimen Retention:   Samples Without DNA

Enrollment: 0
Study Start Date: August 2006
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Individuals with a history of canker sores.
Individuals with no history of canker sores.

Detailed Description:
The purpose of this study is to determine if salivary catecholamines are elevated in patients with the disease aphthous stomatitis. The results of this study will be combined with those performed in collaboration with a co-Investigator to understand the effects of catecholamines on mucosal wound healing and oral epithelial cell migration.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All subjects will be sampled from the community.

Inclusion Criteria:

  • Age 18 or older, both genders
  • History of recurrent aphthous ulcers with 4 or more episodes per year

Exclusion Criteria:

  • History of salivary gland disease including Sjogren's disease, parotitis, and sialolithiasis
  • History of benign or malignant salivary gland tumor
  • History of celiac disease, ulcerative colitis or Crohn's disease
  • Patients on medications that affect salivary flow such as anti-depressants and anti-cholinergic medications
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00556686

Sponsors and Collaborators
University of California, Davis
Principal Investigator: Nasim Fazel, MD, DDS University of California, Davis
  More Information

Additional Information:
No publications provided

Responsible Party: University of California, Davis Identifier: NCT00556686     History of Changes
Other Study ID Numbers: 200614581
Study First Received: November 8, 2007
Last Updated: April 20, 2015
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Stomatitis, Aphthous
Mouth Diseases
Stomatognathic Diseases processed this record on November 30, 2015