Local Anaesthetic for Transvaginal Egg Collection in IVF
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ClinicalTrials.gov Identifier: NCT00554424 |
Recruitment Status
:
Completed
First Posted
: November 6, 2007
Last Update Posted
: November 6, 2007
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Infertility | Drug: lignocaine Drug: normal saline | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 75 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Supportive Care |
Official Title: | A Randomised Controlled Trial of Intravaginal Lignocaine Injection Versus Placebo for Analgesia During Oocyte Recovery in an IVF Cycle |
Study Start Date : | March 2002 |
Actual Study Completion Date : | July 2002 |
Arm | Intervention/treatment |
---|---|
Active Comparator: LA
Intravaginal and pre-peritoneal injection of 1% lignocaine into each side of the upper vagina under ultrasound guidance immediately prior to ultrasound guided transvaginal oocyte retrieval
|
Drug: lignocaine
20 mls of 1% lignocaine solution for injection, 10mls into each side of upper vagina, under ultrasound guidance immediately prior to transvaginal oocyte retrieval under ultrasound guidance from each ovary
|
Placebo Comparator: P
Intravaginal saline placebo injection into each side of upper vagina under ultrasound guidance immediately prior to transvaginal oocyte retrieval
|
Drug: normal saline
20mls of normal saline solution, 10mls injected each side into upper vagina under ultrasound guidance, immediately prior to ultrasound guided transvaginal oocyte retrieval from each ovary
|
- Total dose of iv fentanyl used during oocyte collection [ Time Frame: Length of oocyte collection (minutes) ]
- Pain score (cm on a Visual Analogue Scale) at 6 different points during oocyte collection [ Time Frame: Actual point in time ]
- Length of oocyte collection procedure [ Time Frame: Time taken (minutes) ]
- Occurence of nausea or vomiting [ Time Frame: During oocyte collection procedure ]
- Administration of atropine or anti -emetic [ Time Frame: During oocyte collection procedure ]
- Time spent in recovery room [ Time Frame: Time from end of oocyte collection until discharge home ]
- No of oocytes collected [ Time Frame: During oocyte collection procedure ]
- Number of oocytes fertilised [ Time Frame: Assessed 18 hours after oocyte collection ]
- Pregnancy outcome [ Time Frame: 7 weeks gestation ]
- Number of embryos frozen [ Time Frame: Within 6 days of oocyte collection ]
- Pulse rate at beginning and end of egg collection [ Time Frame: Point in time ]
- Maximum pulse rate during oocyte collection [ Time Frame: Point in time during oocyte collection procedure ]

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Ages Eligible for Study: | Child, Adult, Senior |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- About to undergo transvaginal oocyte retrieval
Exclusion Criteria:
- Already undergone oocyte retrieval and participated in study (i.e. 2nd or more oocyte collection procedure during study period)
- Allergy to lignocaine
- Oocytes only to be collected from one ovary
- Procedure expected to be exceptionally painful

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00554424
New Zealand | |
The Fertility Centre | |
Christchurch, Canterbury, New Zealand, 8014 |
Principal Investigator: | Sarah A Wakeman, FRANZCOG | The Fertility Centre |
ClinicalTrials.gov Identifier: | NCT00554424 History of Changes |
Other Study ID Numbers: |
01/12/180 |
First Posted: | November 6, 2007 Key Record Dates |
Last Update Posted: | November 6, 2007 |
Last Verified: | November 2007 |
Keywords provided by The Fertility Centre, New Zealand:
oocyte retrieval pain relief Local anaesthetic |
Additional relevant MeSH terms:
Infertility Genital Diseases, Male Genital Diseases, Female Anesthetics Lidocaine Anesthetics, Local Central Nervous System Depressants Physiological Effects of Drugs |
Sensory System Agents Peripheral Nervous System Agents Anti-Arrhythmia Agents Voltage-Gated Sodium Channel Blockers Sodium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action |