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Trial record 2 of 11681 for:    Anti-Infective Agents AND antibacterial

The Impact of an Antimicrobial Utilization Program on Antimicrobial Use

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ClinicalTrials.gov Identifier: NCT00552838
Recruitment Status : Completed
First Posted : November 2, 2007
Last Update Posted : November 2, 2007
Sponsor:
Collaborator:
Emory University
Information provided by:
Washington University School of Medicine

Brief Summary:

Multidisciplinary antimicrobial utilization teams (AUT) have been proposed as an effective mechanism for improving antimicrobial use, but data on their efficacy remain limited. The researchers postulated that a multi-disciplinary AUT would improve antimicrobial use in a teaching hospital when compared to the standard of care (no AUT intervention).

Design: Randomized-controlled intervention trial. Setting: A 953-bed urban teaching hospital.

Patients: Patients admitted to internal medicine ward teams who were prescribed selected antimicrobial agents (piperacillin-tazobactam, levofloxacin, or vancomycin) during the 10month study period.

Intervention: Eight internal medicine ward teams were randomized monthly to academic detailing by the AUT while 8 internal medicine ward teams were randomized indication-based prescription of broad spectrum antimicrobials.

Measurements: Proportion of appropriate empiric, definitive, and end antimicrobial usage (antimicrobial use from the initiation of therapy until definitive therapy is prescribed).


Condition or disease Intervention/treatment Phase
Antimicrobial Prescribing Practices Behavioral: Academic Detailing by the Antimicrobial Utilization Team (AUT) Not Applicable

Detailed Description:
This study was conducted when Bernard C Camins, MD (BCC), one of the investigators, was still employed at Emory University. The principal investigator is no longer at Emory University. This trial is being registered by one of the investigators, BCC, so we can submit the manuscript for publication. BCC is now at Washington University and this study was conducted while he was at Emory University.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 785 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Official Title: The Impact of an Antimicrobial Utilization Program on Antimicrobial Use in a Large Public Hospital: A Randomized Controlled Trial
Study Start Date : October 2002
Actual Study Completion Date : August 2003

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
No Intervention: A
Physicians in this arm did not have any intervention with the AUT. Antimicrobial prescriptions were based on hospital guidelines or on the physician's medical knowledge.
Behavioral: Academic Detailing by the Antimicrobial Utilization Team (AUT)
Physicians caring for patients who were prescribed one of three antimicrobials were randomly assigned to academic detailing by the AUT. The AUT would review the antimicrobial prescription and provide consultation to the ordering physician if the prescription is appropriate and provide feedback on a better alternative if inappropriate.




Primary Outcome Measures :
  1. Proportion of Appropriateness of Antimicrobial Prescriptions in each group. [ Time Frame: 10-month period ]

Secondary Outcome Measures :
  1. Clinical Cure Rate, Mortality Rate between the two groups [ Time Frame: 10-month period ]


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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All patients prescribed vancomycin, piperacillin-tazobactam, or levofloxacin during the time period of the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00552838


Locations
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United States, Georgia
Grady Memorial Hospital
Atlanta, Georgia, United States, 30303
Sponsors and Collaborators
Washington University School of Medicine
Emory University
Investigators
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Principal Investigator: Mark D King, MD, MSCR Emory University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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ClinicalTrials.gov Identifier: NCT00552838     History of Changes
Other Study ID Numbers: 579-2002 Emory IRB
First Posted: November 2, 2007    Key Record Dates
Last Update Posted: November 2, 2007
Last Verified: September 2007

Keywords provided by Washington University School of Medicine:
Antimicrobial prescribing
Antimicrobial utilization

Additional relevant MeSH terms:
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Anti-Bacterial Agents
Anti-Infective Agents