Genetic Studies Spermatogenic Failure
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|ClinicalTrials.gov Identifier: NCT00548977|
Recruitment Status : Completed
First Posted : October 25, 2007
Last Update Posted : October 25, 2007
The proposed study is designed to test the following hypotheses:
- Mouse autosomal or X-linked genes which are exclusively expressed in mouse spermatogonia are also spermatogonia-specific in human.
- Severe spermatogenic defect, especially hypospermatogenesis or SCOS, is caused by an intrinsic defect in germ line stem cell or speramtogenia.
- Spermatogonia-specific genes are caudate genes for human spermatogenic defect, especially for hypospermatogenesis or SCOS.
- For a significant fraction of cases with severe spermatogenic defect, the sterile genes are transmitted via multifactorial inheritance mode.
- For some cases with severe spermatogenic defect, mutations of spermatogonia- specific genes may be transmitted in the X-linked recessive, autosomal recessive, or autosomal dominant mode.
|Condition or disease||Intervention/treatment|
|Oligospermia Azoospermia Male Infertility||Other: Drawing blood to study genetic polymorphism|
|Study Type :||Observational|
|Actual Enrollment :||283 participants|
|Observational Model:||Case Control|
|Study Start Date :||January 2001|
|Actual Study Completion Date :||February 2005|
- Genotype/phenotype correlation of Y-linked AZF candidates and estrogen-related genes [ Time Frame: At the time of visiting OPD ]
- Role of significant candidate genes in human spermatogenesis [ Time Frame: At the time of drawing blood ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00548977
|National Cheng-Kung University Hospital|
|Study Chair:||Paolin Kuo, MD|