Genetic Studies Spermatogenic Failure
|ClinicalTrials.gov Identifier: NCT00548977|
Recruitment Status : Completed
First Posted : October 25, 2007
Last Update Posted : October 25, 2007
The proposed study is designed to test the following hypotheses:
- Mouse autosomal or X-linked genes which are exclusively expressed in mouse spermatogonia are also spermatogonia-specific in human.
- Severe spermatogenic defect, especially hypospermatogenesis or SCOS, is caused by an intrinsic defect in germ line stem cell or speramtogenia.
- Spermatogonia-specific genes are caudate genes for human spermatogenic defect, especially for hypospermatogenesis or SCOS.
- For a significant fraction of cases with severe spermatogenic defect, the sterile genes are transmitted via multifactorial inheritance mode.
- For some cases with severe spermatogenic defect, mutations of spermatogonia- specific genes may be transmitted in the X-linked recessive, autosomal recessive, or autosomal dominant mode.
|Condition or disease||Intervention/treatment|
|Oligospermia Azoospermia Male Infertility||Other: Drawing blood to study genetic polymorphism|
|Study Type :||Observational|
|Actual Enrollment :||283 participants|
|Observational Model:||Case Control|
|Study Start Date :||January 2001|
|Actual Study Completion Date :||February 2005|
- Genotype/phenotype correlation of Y-linked AZF candidates and estrogen-related genes [ Time Frame: At the time of visiting OPD ]
- Role of significant candidate genes in human spermatogenesis [ Time Frame: At the time of drawing blood ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00548977
|National Cheng-Kung University Hospital|
|Study Chair:||Paolin Kuo, MD|