Transoesophageal Echocardiography in Liver Transplantation
This study has been completed.
Sponsor:
University of Zurich
Information provided by (Responsible Party):
University of Zurich
ClinicalTrials.gov Identifier:
NCT00547924
First received: October 22, 2007
Last updated: April 9, 2014
Last verified: April 2014
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Purpose
Severe hypotension during reperfusion in liver transplantation is a frequent adverse event. Rare data exist so far about pathophysiology of this phenomenon. The exact role of left ventricular function, which might be impaired causing hypotension, has not been elucidated during the period of reperfusion.
Goal of this study is to:
- perform transesophageal echocardiography in order to assess systolic and diastolic left ventricular function during reperfusion
- determine inflammatory mediators in the plasma which could cause left ventricular dysfunction
| Condition | Intervention |
|---|---|
|
End Stage Liver Disease |
Behavioral: Transoesophageal echocardiography |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Transoesophageal Echocardiography in Liver Transplantation: Left Ventricular Function During Reperfusion |
Resource links provided by NLM:
Further study details as provided by University of Zurich:
| Estimated Enrollment: | 17 |
| Study Start Date: | April 2006 |
| Study Completion Date: | January 2010 |
| Primary Completion Date: | January 2010 (Final data collection date for primary outcome measure) |
Intervention Details:
-
Behavioral: Transoesophageal echocardiography
Transoesophageal echocardiography in liver transplantation: left ventricular function during reperfusion
Eligibility| Ages Eligible for Study: | 18 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Study Population
Patients on waiting list for liver transplantation
Criteria
Inclusion criteria:
- Patients on waiting list for liver transplantation.
- Age: 18-75 years.
Exclusion criteria:
- Strictures, tumours and diverticula of the oesophagus.
- History of oesophageal varices with recent bleeding.
- Oesophageal varices and prothrombin time less than 20% or platetlets les than 30000/ml.
- Instable cervical spine.
- Involvement in other studies.
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00547924
Please refer to this study by its ClinicalTrials.gov identifier: NCT00547924
Locations
| Switzerland | |
| University Hospital Zurich, Institute for Anesthesiology | |
| Zurich, Switzerland | |
Sponsors and Collaborators
University of Zurich
Investigators
| Principal Investigator: | Marco Zalunardo, MD | UniversitaetsSpital Zuerich |
More Information
No publications provided
| Responsible Party: | University of Zurich |
| ClinicalTrials.gov Identifier: | NCT00547924 History of Changes |
| Other Study ID Numbers: | StV 11-2006 |
| Study First Received: | October 22, 2007 |
| Last Updated: | April 9, 2014 |
| Health Authority: | Switzerland: Swissmedic |
Additional relevant MeSH terms:
|
End Stage Liver Disease Digestive System Diseases Hepatic Insufficiency Liver Diseases Liver Failure |
ClinicalTrials.gov processed this record on March 01, 2015