Transoesophageal Echocardiography in Liver Transplantation

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

University of Zurich

ClinicalTrials.gov Identifier:

NCT00547924

First received: October 22, 2007

Last updated: April 9, 2014

Last verified: April 2014

History of Changes

Purpose

Severe hypotension during reperfusion in liver transplantation is a frequent adverse event. Rare data exist so far about pathophysiology of this phenomenon. The exact role of left ventricular function, which might be impaired causing hypotension, has not been elucidated during the period of reperfusion.

Goal of this study is to:

perform transesophageal echocardiography in order to assess systolic and diastolic left ventricular function during reperfusion
determine inflammatory mediators in the plasma which could cause left ventricular dysfunction

Condition	Intervention
End Stage Liver Disease	Behavioral: Transoesophageal echocardiography


Study Type:	Observational
Study Design:	Observational Model: Case-Only Time Perspective: Prospective
Official Title:	Transoesophageal Echocardiography in Liver Transplantation: Left Ventricular Function During Reperfusion

Resource links provided by NLM:

MedlinePlus related topics: Liver Transplantation

U.S. FDA Resources

Further study details as provided by University of Zurich:


Estimated Enrollment:	17
Study Start Date:	April 2006
Study Completion Date:	January 2010
Primary Completion Date:	January 2010 (Final data collection date for primary outcome measure)

Intervention Details:

Transoesophageal echocardiography in liver transplantation: left ventricular function during reperfusion

Eligibility


Ages Eligible for Study:	18 Years to 75 Years (Adult, Senior)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Patients on waiting list for liver transplantation

Criteria

Inclusion criteria:

Patients on waiting list for liver transplantation.
Age: 18-75 years.

Exclusion criteria:

Strictures, tumours and diverticula of the oesophagus.
History of oesophageal varices with recent bleeding.
Oesophageal varices and prothrombin time less than 20% or platetlets les than 30000/ml.
Instable cervical spine.
Involvement in other studies.

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00547924

Locations


Switzerland
University Hospital Zurich, Institute for Anesthesiology
Zurich, Switzerland

Sponsors and Collaborators

University of Zurich

Investigators


Principal Investigator:	Marco Zalunardo, MD	UniversitaetsSpital Zuerich

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Zalunardo MP, Schläpfer M, Beck-Schimmer B, Seifert B, Spahn DR, Bettex D. Impact of cytokine release on ventricular function after hepatic reperfusion: a prospective observational echocardiographic study with tissue Doppler imaging. BMC Anesthesiol. 2015 Jul 25;15:107. doi: 10.1186/s12871-015-0080-2.


Responsible Party:	University of Zurich
ClinicalTrials.gov Identifier:	NCT00547924 History of Changes
Other Study ID Numbers:	StV 11-2006
Study First Received:	October 22, 2007
Last Updated:	April 9, 2014
Health Authority:	Switzerland: Swissmedic

Additional relevant MeSH terms:


Liver Diseases End Stage Liver Disease Digestive System Diseases Liver Failure Hepatic Insufficiency

ClinicalTrials.gov processed this record on September 27, 2016

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