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Transoesophageal Echocardiography in Liver Transplantation

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ClinicalTrials.gov Identifier: NCT00547924
Recruitment Status : Completed
First Posted : October 23, 2007
Last Update Posted : April 10, 2014
Sponsor:
Information provided by (Responsible Party):
University of Zurich

Study Description
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Brief Summary:

Severe hypotension during reperfusion in liver transplantation is a frequent adverse event. Rare data exist so far about pathophysiology of this phenomenon. The exact role of left ventricular function, which might be impaired causing hypotension, has not been elucidated during the period of reperfusion.

Goal of this study is to:

  • perform transesophageal echocardiography in order to assess systolic and diastolic left ventricular function during reperfusion
  • determine inflammatory mediators in the plasma which could cause left ventricular dysfunction

Condition or disease Intervention/treatment
End Stage Liver Disease Behavioral: Transoesophageal echocardiography

Study Design
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Study Type : Observational
Estimated Enrollment : 17 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Transoesophageal Echocardiography in Liver Transplantation: Left Ventricular Function During Reperfusion
Study Start Date : April 2006
Actual Primary Completion Date : January 2010
Actual Study Completion Date : January 2010

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U.S. FDA Resources

Groups and Cohorts
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Intervention Details:
    Behavioral: Transoesophageal echocardiography
    Transoesophageal echocardiography in liver transplantation: left ventricular function during reperfusion

Outcome Measures
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Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients on waiting list for liver transplantation
Criteria

Inclusion criteria:

  • Patients on waiting list for liver transplantation.
  • Age: 18-75 years.

Exclusion criteria:

  • Strictures, tumours and diverticula of the oesophagus.
  • History of oesophageal varices with recent bleeding.
  • Oesophageal varices and prothrombin time less than 20% or platetlets les than 30000/ml.
  • Instable cervical spine.
  • Involvement in other studies.
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00547924


Locations
Switzerland
University Hospital Zurich, Institute for Anesthesiology
Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: Marco Zalunardo, MD UniversitaetsSpital Zuerich
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT00547924     History of Changes
Other Study ID Numbers: StV 11-2006
First Posted: October 23, 2007    Key Record Dates
Last Update Posted: April 10, 2014
Last Verified: April 2014

Additional relevant MeSH terms:
Liver Diseases
End Stage Liver Disease
Digestive System Diseases
Liver Failure
Hepatic Insufficiency