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Differential Metabolic Effects of Statins

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ClinicalTrials.gov Identifier: NCT00546559
Recruitment Status : Completed
First Posted : October 19, 2007
Last Update Posted : August 29, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Condition or disease Intervention/treatment
Hypercholesterolemia Drug: statins (simvastatin, pravastatin)

Study Design

Study Type : Observational
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : January 2004
Estimated Study Completion Date : March 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Primary Outcome Measures :
  1. Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels > 130

Exclusion Criteria:

  • Overt liver disease,
  • Chronic renal failure
  • Hypothyroidism
  • Myopathy
  • Uncontrolled diabetes
  • Severe hypertension
Contacts and Locations

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00546559


Locations
Korea, Republic of
Gil Medical Center
Incheon, Korea, Republic of, 405760
Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
More Information

Publications:
ClinicalTrials.gov Identifier: NCT00546559     History of Changes
Other Study ID Numbers: GMC-200406
First Posted: October 19, 2007    Key Record Dates
Last Update Posted: August 29, 2008
Last Verified: August 2008

Keywords provided by Gachon University Gil Medical Center:
Lipophilic statins
Insulin resistance
simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Additional relevant MeSH terms:
Hypercholesterolemia
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Simvastatin
Pravastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Enzyme Inhibitors