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Differential Metabolic Effects of Statins

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00546559
First Posted: October 19, 2007
Last Update Posted: August 29, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Gachon University Gil Medical Center
  Purpose
The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Condition Intervention
Hypercholesterolemia Drug: statins (simvastatin, pravastatin)

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Gachon University Gil Medical Center:

Primary Outcome Measures:
  • Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Study Start Date: January 2004
Estimated Study Completion Date: March 2008
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels > 130

Exclusion Criteria:

  • Overt liver disease,
  • Chronic renal failure
  • Hypothyroidism
  • Myopathy
  • Uncontrolled diabetes
  • Severe hypertension
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00546559


Locations
Korea, Republic of
Gil Medical Center
Incheon, Korea, Republic of, 405760
Sponsors and Collaborators
Gachon University Gil Medical Center
Investigators
Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00546559     History of Changes
Other Study ID Numbers: GMC-200406
First Submitted: October 18, 2007
First Posted: October 19, 2007
Last Update Posted: August 29, 2008
Last Verified: August 2008

Keywords provided by Gachon University Gil Medical Center:
Lipophilic statins
Insulin resistance
simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.

Additional relevant MeSH terms:
Hypercholesterolemia
Hyperlipidemias
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases
Simvastatin
Pravastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Enzyme Inhibitors