Bevacizumab + Endocrine Treatment vs Endocrine Treatment as First Line Treatment in Postmenopausal Patients With Advanced or Metastatic Breast Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00545077
Recruitment Status : Completed
First Posted : October 17, 2007
Last Update Posted : May 19, 2015
Hoffmann-La Roche
German Breast Group
Information provided by (Responsible Party):
Spanish Breast Cancer Research Group

Brief Summary:

Locally advanced or metastatic breast cancer in postmenopausal women with negative HER2, who are candidates for hormone treatment and who have not received previous chemotherapy or hormonotherapy for the metastatic disease.

The main endpoint of the study is PFS. It has been calculated that 378 patients will need to be included, according to the following assumptions:

  • Recruitment period of 21 months.
  • Minimum follow-up period of 9 months.
  • PFS of 9 months in the control arm (letrozole in monotherapy). Using a two-sided log-rank test, for a 5% α level, 344 patients (172 in each treatment arm) will be required for 270 events to occur, which will provide an 80% power for detecting a hazard ratio of 0.69 (corresponding to a PFS median of 13 months in the bevacizumab arm). This sample size has been adjusted for an intermediate analysis when 2/3 of the total of required events have occurred. This intermediate analysis can be avoided if, at the time in which it must be carried out, it is estimated that the final analysis will be carried out in 4 months.

Taking into account a 10% percentage of losses, 378 patients are expected to be included in the study.

An intermediate safety evaluation will be carried out when 63 patients have finished their treatment in each treatment arm.

Condition or disease Intervention/treatment Phase
Breast Cancer Drug: Endocrine treatment consisting of either letrozole or fulvestrant. Drug: Bevacizumab + Endocrine treatment consisting of either letrozole or fulvestrant. Phase 3

Detailed Description:

A multicenter, randomized phase III clinical trial. After verifying the selection criteria, the patients will be randomized to receive letrozole alone or in combination with bevacizumab. Before randomization, the patients will be stratified according to the following prognosis factors:

  • ER+/PgR+ vs the other options (ER+/PgR- vs ER-/PgR+)
  • Previous adjuvant hormonotherapy (yes/no)
  • Status: locally advanced vs metastatic.
  • Measurable vs non measurable disease
  • Visceral disease (yes/no)
  • PFS.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 378 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Multicenter, Randomized Study to Evaluate the Efficacy and Safety of Bevacizumab in Combination With Endocrine Treatment Compared to Endocrine Treatment Alone, in Postmenopausal Women With Advanced or Metastatic Cancer With Indication of Hormonotherapy as First-line Treatment
Study Start Date : November 2007
Actual Primary Completion Date : December 2013
Actual Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Breast Cancer

Arm Intervention/treatment
Active Comparator: A
• Endocrine treatment consisting of either letrozole or fulvestrant.The patients will be randomized to receive bevacizumab 15mg/kg every 3 weeks plus endocrine treatment or endocrine treatment as a single agent. The patients will receive the assigned treatment until the progression of the disease, unacceptable toxicity or withdrawal of the consent.
Drug: Endocrine treatment consisting of either letrozole or fulvestrant.
The patients will receive the assigned treatment until the progression of the disease, unacceptable toxicity or withdrawal of the consent.

Experimental: B
Bevacizumab: 15 mg/Kg i.v. on day 1 every 3 weeks plus Endocrine treatment consisting of either letrozole or fulvestrant.
Drug: Bevacizumab + Endocrine treatment consisting of either letrozole or fulvestrant.
Bevacizumab will be administered every 21 days (day 1 of cycle 2 will be day 22 of the treatment.The patients will receive the assigned treatment until the progression of the disease, unacceptable toxicity or withdrawal of the consent. Those patients in treatment with bevacizumab who end the study without having progressed will continue to receive the drug out of the study.

Primary Outcome Measures :
  1. ·To compare the progression-free survival (PFS) between both treatment arms. [ Time Frame: 2 years ]

Secondary Outcome Measures :
  1. · Overall survival (OS) · Time to treatment failure (TTF) · Better response to treatment (RR) · Response duration (RD) · Clinical benefit proportion (CBP = CR + PR + SD > 6 months) · Safety and tolerance [ Time Frame: 2 years ]

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Before starting the specific protocol procedures, the written informed consent must be obtained and documented.
  2. Women ≥ 18 years.
  3. Capacity to comply with all the protocol requirements.
  4. Functional ECOG status of 0 or 1.
  5. Life expectancy ≥ 24 weeks.
  6. Histologically confirmed breast adenocarcinoma, with measurable or non-measurable, locally advanced or metastatic (stage IV) disease. In the event that the patient only has locally advanced disease, she will not be able to undergo curative local treatment. Patients with metastasis confined to the bone can be chosen, but the disease must be confirmed by radiology, CT scan or NMR if there is any doubt after a single bone scan.
  7. Patients with HER2-negative disease evaluated by IHC and FISH/CISH (IHC 0 or 1+, or 2+ and negative FISH). Patients with 3+ by IHC cannot be chosen regardless of the FISH/CISH status and those with positive FISH/CISH (> 2 amplifications) cannot be chosen either, regardless of the IHC findings.
  8. Positive hormone receptors (estrogen receptor [ER] and/or progesterone receptor [PgR]) evaluated by a local or central laboratory, according to the criteria of the participating institution.
  9. Patients who are candidates for receiving first-line treatment with letrozole.
  10. Patients may have received (neo)adjuvant chemotherapy, provided that the last dose of the latter was received at least 12 months before randomization . Patients must be recovered from toxicity.
  11. The patients are allowed to have received adjuvant radiotherapy, provided that it was completed at least 6 weeks before randomization and the patient has recovered from the reversible acute effects of the radiation. The previous administration of radiotherapy to palliate the pain of bone metastases is authorized, provided that:

    • Not more than 30% of bone marrow has been irradiated.
    • The patient has recovered from the reversible acute effects of the radiation.
    • The patient has at least one metastatic location which has not been irradiated and which may be evaluated for progression, or a clear progression of the bone disease has been objectified after the end of the palliative radiotherapy.
  12. The patients may have received any kind of previous (neo)adjuvant hormone therapy provided that they are considered to be candidates for first-line hormonotherapy with either letrozole or fulvestrant.
  13. The treatment with bisphosphonates is allowed and recommended for patients with bone metastases. Whenever it is possible, the treatment should be started before or within the 4 weeks of starting the study therapy. The patients starting treatment with bisphosphonates must be carefully evaluated so that they do not mask the progression of the disease.
  14. In the patients with heart failure risk (e.g. previously treated with > 360mg/m2 of doxorubicin or equivalent doses of other anthracyclines), the LVEF must be determined by means of an echocardiogram or radionuclide ventriculography (MUGA), and it must t be > the lower limit of normal.

Exclusion Criteria:

  1. Evolutionary disease requiring an immediate treatment with cytotoxic chemotherapy according to the investigator's judgment.
  2. Patients with locally advanced breast cancer who are expected to undergo surgery or curative radiotherapy.
  3. Previous chemotherapy or hormonotherapy for the metastatic disease. Patients may have received neoadjuvant chemotherapy or neoadjuvant hormonotherapy with curative intention as a part or as an alternative to an adjuvant treatment. For the previous neoadjuvant hormonotherapy the same premises than for the adjuvant hormonotherapy are valid.
  4. Previous therapy with anti-VEGF or VEGFR tyrosine-kinase inhibitors.
  5. History of another pathology that may affect the development of the protocol or the interpretation of results. It is considered that patients who have suffered from a skin carcinoma that is not melanoma, cervical carcinoma in situ or another neoplasia treated with a curative intention and with a disease-free interval exceeding 5 years can be chosen.
  6. Evidence of CNS metastasis. A CT scan or brain NMR must be done within the 4 weeks before the randomization in case of suspecting brain metastasis.
  7. History or evidence in the physical or neurological examination of CNS pathology unrelated to cancer unless it is suitable treated with standard therapy (e.g. uncontrolled convulsions).
  8. History of peripheral neuropathy NCI CTCAE grade >2 at the time of randomization.
  9. Patients subjected to major surgical procedures, open biopsies or those having significant trauma injuries within the 28 days prior to randomization, or patients who are expected to undergo a major surgical procedure that must necessarily be performed within the course of the study.
  10. Minor surgical procedures in the 7 days prior to randomization.
  11. Unsuitable bone marrow supply: ANC < 1.5 x 109/L, platelets < 100 x 109/L or Hb < 10 g/dL.
  12. Impaired liver function: total bilirubin total > 1.5 x ULN, AST and ALT > 2.5 x ULN (> 5 x ULN in patients with liver metastases).
  13. Impaired kidney function:

    1. Serum creatinine > 2.0 mg/dL or 177 µmol/L.
    2. Proteinuria determined by reactive strip > 2+. A 24h determination of proteins in urine will be requested for the patients with > 2+ in the baseline analysis and must have a protein figure < 1 g/24 h.
  14. Chronic treatment with oral corticoids (dose > 10 mg/day of methylprednisolone or equivalent): the use of inhaled corticoids is allowed.
  15. Chronic treatment with acetylsalicylic acid (> 325 mg/day) or clopidogrel (> 75 mg/day).
  16. Uncontrolled arterial hypertension (systolic > 150 mm Hg and/or diastolic > 100 mm Hg) or clinically significant cardiovascular disease: for example CVA (in the 6 months prior to randomization), coronaropathy or history of AMI in the last 6 months, unstable angina, congestive heart failure of grade > II of the New York Heart Association (NYHA) or severe heart arrhythmias which are not controlled with medication or which can potentially interfere with the study treatment.
  17. History or evidence of hemorrhagic diathesis or coagulopathy with bleeding risk.
  18. History of abdominal fistula, gastrointestinal perforation or intra-abdominal abcess in the 6 months prior to randomization.
  19. Active infection requiring i.v. antibiotics at the time of randomization.
  20. Unhealed wounds, active peptic ulcer, esophageal varices.
  21. Any other disease, psychological or metabolic alteration, found in the physical or laboratory examination, providing reasonable indications for suspecting a disease or complaint for which the use of any of the study drugs are contraindicated, or which may affect the patient's compliance with the routine procedures of the study or which places the patient at a high risk of experiencing complications related to the treatment.
  22. Current or recent (within 30 days prior to that start of the study treatment) treatment with another drug under investigation or participation in another investigation study.
  23. Known hypersensitivity to any of the study drugs or their components.
  24. Hypersensitivity to the products of Chinese hamster ovary cells or to other human or humanized recombinant antibodies.

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00545077

  Show 85 Study Locations
Sponsors and Collaborators
Spanish Breast Cancer Research Group
Hoffmann-La Roche
German Breast Group
Study Director: Sibylle Loibl, PhD., MD. GBG Forschungs GmbH
Study Director: Miguel Martín, PhD., MD Hospital Clínico San Carlos
Study Director: Juan De la Haba, PhD., MD. Hospital Provincial de Córdoba

Additional Information:
Responsible Party: Spanish Breast Cancer Research Group Identifier: NCT00545077     History of Changes
Other Study ID Numbers: GEICAM/2006-11/GBG 51
Nº EudraCT: 2007-002841-19
First Posted: October 17, 2007    Key Record Dates
Last Update Posted: May 19, 2015
Last Verified: October 2014

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents
Aromatase Inhibitors
Steroid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Estrogen Antagonists
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Antineoplastic Agents, Hormonal
Estrogen Receptor Antagonists